目的    观察IL-6与上皮-间质转化（EMT）因子在胃癌组织表达情况相关性及其与病人预后的关系。方法    采用免疫组化法检测上海交通大学医学院附属新华医院病理科2006年9月至2008年2月间60例手术切除胃癌组织和60例配对正常胃黏膜组织中IL-6，Twist，E-caherin及Vimentin蛋白的表达。结果    胃癌组织中IL-6、Twist及Vimentin表达阳性率、E-cadherin表达阴性率均比正常胃黏膜组织中高，并与胃癌的分化程度、TNM分期、淋巴结转移情况、浸润深度以及生存期较短有显著相关性（P<0.05），与性别、年龄及肿瘤大小无关。IL-6的表达与Twist、Vimentin表达呈正相关，与E-cadherin表达呈负相关。结论    IL-6蛋白的表达与EMT相关蛋白、胃癌侵袭转移以及临床预后因素相关，可为胃癌侵袭转移的研究和病人的预后判断提供有价值的参考。

Correlation between IL-6 expression and epithelial-mesenchy-maltransitions in gastric cancer and its clinical significance        MA Fei*, ZHANG Ming-di, WANG Ya-jie. *Department of Oncology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Corresponding author: WANG Ya-jie, E-mail: njl1@163.com
Abstract    Objective    To investigate the relationship between IL-6 expression and epithelial-mesenchy-maltransitions（EMT）in gastric cancer and to study its effect on infiltration, metastasis and the prognosis of patients with gastric cancer. Methods    The expressions of IL-6, Twist, E-cadherin and Vimentin in 60 cases of gastric cancer and 60 cases of normal mucosa tissues were detected by using immunohistochemistry. Results    Significant overexpression of IL-6, Twist and Vimentin, low-expression of E-cadherin were observed in gastric cancer and they were correlated with differentiation degree, TNM stage, lymph node metastasis, infiltrated depth and short survival time rather than gender, age and tumor size. The expression of IL-6 was correlated positively with the expression of Twist and Vimentin, negatively with the expression of E-cadherin. Conclusion    IL-6 positive expression is related to EMT-related factors, metastasis of gastric cancer and clinical prognostic factors, which might be valuable basis for the study of infiltration, metastasis and prognosis.