目的    探讨早期乳腺癌前哨淋巴结活检结果的相关影响因素。方法    2008年1月至2013年1月新疆医科大学附属肿瘤医院收治252例行前哨淋巴结活检术早期乳腺癌病人，总结临床、病理特征，对影响前哨淋巴结活检结果的因素进行分析。结果    单因素分析显示病灶大小、术前影像学腋窝评价、Her-2、Ki-67、组织学分级、分子分型因素对前哨淋巴结的病理结果有影响，差异有统计学意义，其中分子分型中相对于Lumina A型病人，其他早期乳腺癌分子分型病人行前哨淋巴结活检术较易出现阳性结果，多因素分析显示病灶大小与Ki-67表达对前哨淋巴结活检阳性结果有影响，差异有统计学意义。结论    早期乳腺癌病人术前相关临床病理资料可预测前哨淋巴结活检结果，对病人的进一步治疗有一定的指导作用。

Analysis of related factors of positive results for sentinel lymph node biopsy in patients with early breast cancer          LI Yong-tao，NI Duo，YANG Liang，et al. Department of Breast Surgery, Xinjiang Medical University Cancer Institute and Hospital， Urumqi 830011, China
Corresponding author:ZHU Li-ping, E-mail：doctorzhuliping@yahoo.com.cn
Abstract    Objective    To explore the factors related to early breast cancer patients underwent sentinel lymph node biopsy. Methods    A total of 252 patients with early breast cancer underwent sentinel lymph node biopsy between January 2008 and January 2013 in Xinjiang Medical University Affiliated Tumor Hospital. The clinical pathological characteristics were summarized. The influencing factors of sentinel lymph node biopsy results were analyzed. Results Univariate analysis showed that tumor size，preoperative imaging evaluation,  Her-2，Ki-67， histological grade，molecular typing were correlated with pathologic result of sentinel lymph node biopsy，and the difference was significant statistically. Compared with Lumina type A patients，other early breast cancer molecular subtypes patients underwent sentinel lymph node biopsy were prone to positive results. Multivariate analysis showed that tumor size and Ki-67 expression were correlated with positive results of sentinel lymph node biopsy，and the difference was significant statistically. Conclusion    Preoperative pathological data of early breast cancer patients can predict sentinel lymph node biopsy results，which have certain guidance for further treatment of patients.