肝脏腺瘤是一种少见的肝脏良性肿瘤，多发生于青年女性。据报道，发病与长期应用口服避孕药密切相关。肝脏腺瘤无特异性的临床表现，诊断主要依靠影像学检查及活检。肝脏腺瘤具有易出血、易恶变的特点，临床上需积极干预处理。近来通过分子生物学技术，将肝脏腺瘤分为特点明显的3个大类：炎性肝脏腺瘤、肝细胞核因子1α变异性肝脏腺瘤和β连环蛋白激活肝脏腺瘤。3个亚类在病理学特征、癌变预后等方面均不相同，为进一步个体化治疗提供了依据。

Standardized management of hepatocellular adenomas              YU Lei, ZHOU Jian. Liver Cancer Institute and Zhongshan Hospital, Fudan University; Carcinogenesis and Invasion, Ministry of Education Key Laboratory, Shanghai200032, China
Corresponding author: ZHOU Jian, E-mail：zhou.jian@zs-hospital.sh.cn
Abstract    Hepatocellular adenomas (HCAs) are rare benign liver tumors that commonly occur in young women and strongly associated with the use of oral contraceptive pills. HCAs have no specific manifestation and the diagnoses are mainly made upon imaging and biopsy. Bleeding and malignant transformation are two major complications of HCAs. Thus it needs active surgical strategy to remove the tumor. Recently HCAs are classified into 3 distinct subtypes by molecular biology techniques such as inflammatory HCAs，hepatocyte nuclear factor-1 mutated HCAs and β-catenin activated HCAs. Each subtype has a characteristic histopathology，oncogenesis and so on, which provide evidences for further individualized therapy.