肝脏局灶性结节性增生是发病率仅次于肝血管瘤的肝脏良性肿瘤。影像学技术的快速发展使肝脏局灶性结节性增生的确诊不需要活检或切除。虽然已经有较多的研究，并将该病分成了多种亚型，但是其发病机制及自然病程的发展并不完全清楚。肝脏局灶性结节性增生是一种良性非进展性病变，其主要临床策略是密切观察。但是由于其难与肝腺瘤及原发性肝癌鉴别，故其临床治疗尚无统一标准，外科干预指证亦不明确。因此，尚须进一步的高循证医学证据指导临床治疗，既要避免盲目手术，更要避免漏诊和误诊而延误治疗。

Diagnosis and standardized management of hepatic focal nodular hyperplasia        SUN Jian，WANG Jie.  Department of General Surgery, SUN Yat-sen Memorial Hospital, SUN Yat-sen University, Guangzhou 510038, China
Corresponding author: WANG Jie, E-mail: sumsjw@163.com
Abstract    Hepatic focal nodular hyperplasia is the second most common benign liver tumor after hepatic hemangioma. The rapid developments in imaging technology have allowed more accurate diagnoses without the need for biopsy or resection. Although there have been lots of research about focal nodular hyperplasia，and the disease has been divided into several subtypes，the development of the pathogenesis and natural history is not clear entirely. Hepatic focal nodular hyperplasia is a benign non-progressing lesions，and its main clinical strategy is observation closely. However，due to the difficult identifications between hepatic focal nodular hyperplasia and hepatic adenoma or primary liver cancer，the clinical management has no uniform standards and the indication of surgical intervention is not clear. Therefore，the high quality evidences of evidence-based medicine are still need to support the clinical management，not only to avoid blind operation，but also to avoid the misdiagnosis and delayed treatment.