结直肠癌肝转移的治疗进步一直得益于多学科综合治疗水平的提高和发展，但临床上仍然有许多问题没有解决，包括化疗方案的优化、靶向药物联合化疗的利弊、药物安全性以及化疗时机等，特别是相继有关结直肠癌肝转移术后辅助化疗或靶向治疗失败后，人们越来越关注手术前的药物治疗以及转化治疗。有效的药物治疗为结直肠癌肝转移提供了更多的手术切除和延长生存机会，合理选择化疗药物和靶向联合、恰当的药物治疗时长和停药机会是提高结直肠癌肝转移综合治疗水平的前提之一。

Advance of chemotherapy and targeted therapy in colorectal liver metastases        SHEN Lin. Department of Gastroenterology, Peking University Cancer Hospital, Beijing 100142，China
Abstract    Advances in the treatment of colorectal liver metastases (CRLM) have benefited from the development of multidisciplinary treatment. But many problems are still unresolved in clinical practice including optimization of chemotherapy, advantages and disadvantages of combination of targeted therapy with chemotherapy, safety and chemotherapy timing, etc. Especially after the failure of CRLM adjuvant chemotherapy or targeted therapy, there is a growing concern about preoperative treatment and conversion therapy. Effective chemotherapy can provide more opportunities of radical resection and prolonged survival. Rational option of combination of targeted therapy with chemotherapy, correct chemotherapy duration and withdrawal time are the keys to improve management level of CRLM.