结直肠癌肝转移发生率高，且临床就诊者大多数肝转移灶为不可切除。尽管关于不可切除结直肠癌肝转移病人原发灶的处理尚有一定争议，但随着结直肠癌原发灶处理经验的积累，多学科综合治疗团队（MDT）模式的开展，转化性治疗思维的应用，“个体化治疗”原则的实施，针对不可切除结直肠癌肝转移病人原发灶的处理逐步形成包括手术切除原发灶在内较合理的综合治疗体系。手术切除、新辅助治疗与姑息治疗的合理选择是改善不可切除结直肠癌肝转移病人生存质量及提高生存期，获得最佳治疗效果的关键。

Treatment of the primary cancer of patients with unresectable colorectal liver metastases        DAI Dong-qiu, ZHANG Chun-dong. Department of Gastrointestinal Surgery, the Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China. 
Corresponding author: DAI Dong-qiu, E-mail: daidq63@163.com
Abstract    The incidence of colorectal liver metastases (CRLM) is high and liver metastases of most patients with colorectal cancer in China are unresectable. Although there are still conflicts on the treatment of the primary cancer of CRLM, a systematical therapy system including the surgical resection of primary cancer has been established with the accumulation of experience on primary cancer management, the starting of the multidisciplinary team (MDT), the application of conversion therapy, the implement of individual therapy principle. However, the rational choose of surgical resection, neoadjuvant therapy and palliative care is the key to improve patients’ life quality and achieve the best therapy effects for patients with unresectable CRLM.