胃癌和食管癌是全球癌症相关死亡的主要原因之一。在发达国家，胃癌的发病率降低，与之相反，食管胃结合部腺癌（AEG）的发病率迅速上升。已有的文献表明AEG的病因、诊断标准及临床病理特征存在许多差异。许多AEG的组织发生与Barrett食管密切相关，发病经过从肠上皮化生→低级别异型增生→高级别异型增生→腺癌几个阶段。

Clinicopathological features of adenocarcinoma of the esophagogastric junction        SUN Yu, LI Ji-you. Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing100142, China
Corresponding author: SUN Yu, E-mail: sunyu_bch@163.com
Abstract    Gastric and esophageal cancers are among the leading causes of cancer-related death worldwidely. By contrast with the decreasing prevalence of gastric cancer, incidence and prevalence of adenocarcinoma of the esophagogastric junction (AEG) are rising rapidly in developed countries. Many discrepancies exist in the published work about the causes, diagnostic criteria and clinicopathological features of AEG. Histogenesis of most AEG is related with Barrett’s esophagus. The pathogenic process includes intestinal metaplasia, low grade dysplasia, high grade dysplasia and adenocarcinoma.