随着经济发展与人口老龄化，外周血管疾病的发病率逐年上升。血小板的黏附、激活和聚集在外周血管疾病发生和发展进程中起着重要的作用，通过有效的抗血小板治疗，能够显著降低这些病人心血管事件的发生率。对存在高危因素的病人，采用抗血小板药物进行二级预防能够有效减少心血管事件的发生。然而对于有些病人，抗血小板治疗并不能取得理想的疗效，反而增加了出血的风险，应引进重视。

Clinical role and effect of antiplatelet therapy in peripheral vascular disease treatment        WANG Mian, CHANG Guang-qi. Department of Vascular Surgery, the First Affiliated Hospital of Sun Yat-sen University,Guangzhou510080,China
Corresponding author: CHANG Guang-qi, E-mail：changguangqi@yahoo.com.cn
Abstract    As economy growing and society aging, the incidence of peripheral vascular diseases (PVD) increases year after year. Platelet adhesion, activation and aggregation play pivotal steps in the process of PVD. Effective antiplatelet therapy could decrease the incidence of cardiovascular events in PVD patients significantly. Antiplatelet therapy for the secondary prevention could reduce the incidence of cardiovascular events in PVD patients with high risks effectively. However, reduced responsiveness to antiplatelet therapy is found in some patients and could increase risk of bleeding.