慢性胰腺炎与胰腺癌关系密切，慢性胰腺炎病人胰腺癌发生风险增加。其癌变机制尚不明确，多种细胞因子及信号通路参与慢性胰腺炎癌变过程。肿块型慢性胰腺炎与胰腺癌临床表现及影像学特征相似，术前鉴别诊断困难，内镜超声引导下细针穿刺活检（EUS-FNA）及PET/CT具有很好的鉴别诊断价值。

Advances in canceration of chronic pancreatitis and diagnosis        ZHANG Tai-ping,XU Jian-wei,ZHAO Yu-pei. Department of Surgery, Peking Union Medical College Hospital , Peking Union Medical College , Chinese Academy of Medical Science , Beijing 100730 , China
Corresponding author：ZHAO Yu-pei,E-mail：zhao8028@263.net
Abstract    Chronic pancreatitis is closely related to pancreatic cancer. Patients with chronic pancreatitis have a markedly increased risk of pancreatic cancer compared with the general population. The nature of the transition between chronic inflammation and cancer is still a subject of debate. In the setting of CP, inflammatory cells, cytokines, chemokines, and activated signaling pathways play a role in the transformation of normal ductal epithelium to metaplastic metaplasia and early neoplastic lesions (pancreatic intraepithelial neoplasia (PanIN)), which eventually give rise to pancreatic cancer.Mass-forming chronic pancreatitis is similar with pancreatic cancer in clinical manifestation and imaging characteristic.It is difficult to differentiate mass of the head of pancreas. EUS-FNA and PET/CT is useful to differential diagnosis.