中国实用外科杂志

中国实用外科杂志 ›› 2011, Vol. 31 ›› Issue (08): 688-692.

• 论著 • 上一篇    下一篇

保留幽门胃部分切除术治疗早期胃癌临床效果及生活质量系统评价

梁冀望，宋永喜，孙景旭，徐惠绵，王振宁   

  1. 中国医科大学附属第一医院肿瘤外科 中国医科大学附属第一医院普通外科教研室胃肠肿瘤外科，辽宁沈阳110001
  • 出版日期:2011-08-01 发布日期:2011-08-01

  • Online:2011-08-01 Published:2011-08-01

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摘要：

目的    系统评价保留幽门胃部分切除术（PPG）治疗早期胃癌的临床效果及生活质量。方法    计算机检索1995年1月至2010年12月PubMed、Wiley Online Library、中国生物医学数据库（CBM）、CNKI、VIP及万方数据库关于PPG和传统远端胃切除术（CDG）治疗早期胃癌的随机对照试验。RevMan 5.0进行Meta分析。结果    纳入2个随机对照试验和11个临床对照试验，共1011例病人。PPG和CDG相比，术后能减少倾倒综合征、残胃炎的发生，病人营养状况和体重恢复较好；但总并发症、胆结石、反流性食管炎无显著差别。结论    现有研究表明，早期胃癌行PPG后生活质量较好。由于纳入研究方法学质量低、数量少，期待更多高质量试验提供高质量证据。

关键词: 胃远端切除术, 生活质量, Meta分析, 早期胃癌, 保留幽门胃切除术

Abstract:

Clinical efficacy and quality of life of pylorus-preserving gastrectomy for early gastric cancer: a Meta-analysis      LIANG Ji-wang, SONG Yong-xi, SUN Jing-xu, et al. Department of Surgical Oncology and General Surgery, the First Hospital of China Medical University, Shenyang 110001, China.
Corresponding author: WANG Zhen-ning, E-mail：josieon826@yahoo.com.cn
Abstract    Objective    To assess the clinical efficacy and postoperative quality of life of pylorus-preserving gastrectomy(PPG) for early gastric cancer. Methods    Literature search was performed in PubMed, Wiley Online Library, Chinese Biomedical Database(CBM), CNKI, VIP and Wanfang to identify clinical randomized controlled trails on PPG and conventional distal gastrectomy (CDG) for early gastric cancer published between January 1995 and November 2010.RevMan 5.0 software was used for statistical analysis. Results    A total of 13 studies involving 1011 patients were included. Meta-analysis showed that compared with PPG group, early dumping syndrome, gastritis were more common in CDG group. Nutritional status and the average relative body weight in PPG group were better than those in CDG group significantly. However, there were no significant differences between the two groups in complications, gallstones and reflux esophagitis. Conclusion    PPG is safe and effective for the treatment of patients with early gastric cancer, which may have a better postoperative quality of life. Due to the poor quality and small sample size of included trials, more well-designed randomized controlled trials should be performed.

Key words: pylorus-preserving gastrectomy, distal gastrectomy, quality of life, early gastric cancer, Meta-analysis