原发性胆囊癌是胆道系统中占首位的恶性肿瘤，预后差，5年存活率低，仅为5%~13%，手术切除是治愈胆囊癌的最有效方法，胆囊癌外科手术方式的选择主要取决于病人的一般情况、肿瘤局部病变情况和胆囊癌的分期，目前早期胆囊癌Nevin I期行单纯胆囊切除术，II~V期胆囊癌多需扩大切除范围包括肝脏、胆囊床切除，以及清扫包括胆囊三角淋巴结及周围的区域淋巴结，化疗、放疗均能有效延长病人生存期。

Combined therapy of gallbladder carcinoma        LUO Meng, XU Qing. Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
Corresponding author:LUO Meng,E-mail:forever.ye@gmail.com
Abstract    The primary gallbladder carcinoma is the most common malignant tumors in the biliary system, which has poor prognosis with 5%~13% actuarial survival at 5 years. Resection is the certain means for patients with gallbladder carcinoma. The decision about the type of resection to be performed should be mostly based on patients’ status, tumor characteristics and Nevin stage. The early gallbladder carcinoma with Nevin I stage only need simple cholecystectomy. A more aggressive surgical approach, including resection of the liver, gallbladder bed and regional lymph nodes is advisable for patients with Nevin II to V tumors. Chemotherapy and radiation treatment are valid to prolong survival.