结直肠癌的新辅助治疗应遵循以下原则：（1）对于II期，III期的直肠癌病人应进行术前新辅助治疗。具体方案可采用放疗或放化疗联合。但不推荐单纯化疗。（2）对于不伴有远处转移的结肠癌病人不推荐术前新辅助治疗。仅对于可切除结肠癌肝转移病人可行新辅助化疗，以达缩小病灶，杀灭潜在转移灶之目的。

Neoadjuvant therapy of colorectal cancer        GU Jin, DU Jing-zeng. Department of Colorectal Surgery, Beijing Cancer Hospital ,Beijing100142,China
Corresponding author:GU Jin, E-mail: zlguj@yahoo.com.cn
Abstract    The principles of neoadjuvant therapy in colorectal cancer are as follows: 1. Rectal cancer patients of stage II and III should under neoadjuvant therapy. Specific strategies could be radiotherapy or with concurrent chemotherapy. Chemotherapy alone is not recommended. 2. Neoadjuvant chemotherapy is not recommended in colon cancer patients without metastasis. It is suggested only for patients with resectable liver metastasis to achieve the aim of tumor recession and diminishing micrometastasis.