胃肠间质瘤（gastrointestinal stromal tumors，GIST）的发生与kit和PDGFR?α基因突变相关，有其独特的临床和病理特征。免疫组化的染色有助于GIST的诊断，而基因突变点的检测对临床应用伊马替尼和舒尼替尼治疗具有重要的指导意义。

The clinical significance of mutation detection in the gastrointestinal stromal tumors        WANG Ya-jie. Department of Oncology, Changhai Hospital Attached to the Second Military Medical University,Shanghai 200433,China
Abstract    Gastrointestinal stromal tumor (GIST) is a specific clinicopathologic entity characterized by activating mutations of kit and PDFGR-αgenes. The immunohistochemical staining is frequently used to confirm the diagnosis. However, the demonstration of kit and PDFGR-α mutations has been shown to be more reliable in establishing the clinical significance for application of imatinib and sunitinib.