目的 探讨超声引导下导丝定位手术活检在临床不能触及肿块的乳腺病变中的价值及可行性。方法 收集2007 年3 月至2008 年12 月间北京世纪坛医院乳腺外科收治57 例女姓病人，对超声发现的60 个临床不能触及的乳腺病灶行导丝定位手术活检及病理检查。结果 60 个病灶均一次定位成功，发现乳腺癌14 例，占24.6%，轻至中度导管或小叶上皮非典型增生16 例,占28%。结论 应谨慎处理临床触诊阴性但超声下异常的乳腺病灶；超声引导下导丝定位活检可以发现容易漏诊的早期乳腺癌及癌前病变；该方法简便、准确，值得推广。

Ultrasound-guided wire-localized surgical biopsies for nonpalpable breast lesions LI Yan-ping*, GAO Hong, WANG Hui-yu, et al. *Department of Breast Disease, Beijing Shijitan Hospital, Beijing 100038，China Corresponding author: LI Yan-ping, E-mail: liyanping112@yahoo.com.cn Abstract Objective To investigate the value and feasibility of wire-location surgical biopsies by ultrasound for non-palpable breast lesions. Methods Between March 2007 and December 2008, 57 women with 60 non-palpable breast lesions underwent surgery at Beijing Shijitan Hospital. Wire localization guided by ultrasound was performed before operation. Results All lesions founded by ultrasound were accurately localized and excised. Forteen (24.6%) cases were malignant and 16(28%) were ductal or lobular atypical hyperplasia by pathologic diagnosis. Conclusion Careful consideration should be taken for the cases of non-palpable breast lesions. Ultrasound-guided wire localization of breast lesions is useful in assisting surgical biopsy and worth extensive generalization.