肝内胆管癌的发生与长期反复的胆道感染和胆管内皮的慢性损伤密切相关。其大体形态上可分为肿块型、结节型、乳头型及弥漫硬化型,组织学类型以管状腺癌为主。肝胆管结石合并肝胆管癌的误诊率较高,早期诊断率低，B超和CT增强检查最为常用且价值较高。根治性的肝叶切除是首选的治疗方法，肝移植术也是一种有效的治疗措施。本病预后较差。

Cholelithiasis complicated with cholangiocarcinoma DOU Ke-feng, AN Jia-ze. Department of Hepatobilliary Surgery，Xijing Hospital, the Fourth Military Medical University，Xi'an 710032，China Corresponding author: DOU Ke-feng, E-mail：gdwk@fmmu.edu.cn Abstract The occurrence of intrahepatic cholangiocarcinoma was closely related to the biliary tract long-term recurrent infection and bile duct endothelial chronic injury. Its general shape can be divided into the tumor type, nodular type, papillary type and diffuse sclerosis type. Tubular adenocarcinoma was main histological type. Hepatolithiasis with hepatic cholangiocarcinoma exist high misdiagnosis rate, low early diagnosis rate, B ultrasound and CT enhance inspection are most commonly used and with higher value. Radical resection of the liver is the preferred method of treatment, liver transplantation is an effective treatment measure. The prognosis of this disease is poor.