目的 探讨胰十二指肠切除术（pancreatoduodenectomy，PD）中胰肠吻合技术的改进，以期减少胰漏的发生。方法 回顾性分析第二军医大学东方肝胆外科医院2006年3月至2008年3月完成的21例PD的临床资料。所有病例均采用首层吻合为胰腺全层与空肠浆肌层交叉褥式缝合的套入式端侧胰肠吻合方式。结果 无一例发生胰漏，2例发生胃肠吻合口出血，无手术死亡。结论 该吻合方式吻合牢靠、操作简便确实，能明显降低胰漏的发生率，值得推广应用。

Application of modified end-to-side invagination pancreaticojejunostomy in pancreatoduodenectomy: an analysis of 21 cases ZHANG Bao-hua，YANG Jue，LI Nan，et al. Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200438, China Corresponding author: ZHANG Bao-hua, E-mail: zhbh_1@tom.com Abstract Objective To investigate the improvement of pancreaticojejunostomy technique in pancreatoduodenectomy (PD), in order to decrease incidence of pancreatic leakage. Methods The clinical data of 21 cases of PD admitted between March 2006 to March 2008 at the Second Military Medical University was analyzed retrospectively. Intersection mattress suture was used for pancreaticojejunostomy that suture full-thickness of pancreas and seromuscular layer of jejunum at first layer. Results No pancreatic leakage occurred in the cases. Two cases of postoperative bleeding of gastrointestinal anastomosis occurred. No postoperative death occurred. Conclusion Intersection mattress suture is a safe and feasible method. The method is effective to decrease incidence of pancreatic leakage and it is valuable to be generalized and applied.