目的 探讨结直肠黏液腺癌与印戒细胞癌临床病理特点和预后及其关系。方法 分析中山大学附属第一医院胃肠胰外科1994—2007年收治的2089例原发性结直肠癌中的黏液腺癌144例，印戒细胞癌25例的临床资料，比较结直肠黏液腺癌与印戒细胞癌临床病理特点和预后及其之间的关系。 结果 黏液腺癌占结直肠癌的5.45%，印戒细胞癌占1.19%；黏液腺癌与印戒细胞癌相比, 印戒细胞癌发病年龄更年轻, 女性易发病, 黏液腺癌好发于结肠而印戒细胞癌好发于直肠（P<0.01）;但在肿瘤直径、淋巴结转移和远处转移和浆膜浸润﹑脏器侵犯﹑根治性切除率﹑中晚期比例等方面二者差异无统计学意义（P>0.05）；印戒细胞癌与黏液腺癌总体存活率相比差异有统计学意义（P<0.05）,可根治手术组总体存活率相比差异有统计学意义（P<0.05）。 结论 印戒细胞癌与黏液腺癌是生物学行为相近而且具有独特的癌变机制的肿瘤，结直肠黏液癌尤其是印戒细胞癌是结直肠癌独立的预后危险因素，其预后差的原因可能与其发生部位和独特的病理类型有关。

Clinicopathologic features and survival of mucinous and signet-ring cell adenocarcinoma of the colon and rectum SONG Wu, HE Yu-long, CAI Shi-rong, et al. Department of Gastrointestinopancreatic Surgery, the First Affiliated Hospital of Sun Yet-San University, Guangzhou 510080,China Corresponding author: HE Yu-long, E-mail: YLH@medical.com Abstract Objective To investigate the clinicopathological characteristics and prognosis of colorectal mucinous (MC) and signet-ring cell(SR) adenocarcinoma. Methords Patients diagnosed as mucinous (n=144, 5.45%), signet-ring cell(n=25, 1.19%) carcinoma of all 2 089 cases of colorectal cancer from 1994 to 2007 in a single institution were evaluated. The clinicopathological parameters and survival of mucinous and signet-ring cell were analyzed retrospectively. Results Compared with MC, the SR were found to be more common in female and younger age group（P<0.01）. The SR was more often located in rectum while mucinous more in colon（P<0.01）. There was no significant difference in tumor size, lymph node metastasis, distant metastasis, serosal infiltration, adjacent organ invasion, radical resectional rate and the ratio of patients of later stage（P>0.05）.In compare of MC patients with SR tumors were worse in long-term overall survival , survival in the group of receiving radical resection. (P<0.05). Conclusion Mc and SR adenocarcinoma have unique mechanism of carcinogenesis and similar biological behavior, and both of them, especially signet-ring cell carcinoma, were independent prognostic factor for patients with colorectal cancer. The results may resulted from the location and special pathologic type.