目的评价乳管镜下放置定位针对未扪及肿块的乳管内占位性病变的定位价值。方法北京友谊医院2006年8月至2008年3月对92例临床未扪及肿块的乳头溢液病人进行117次乳管镜检查，发现24例乳管内占位性病变，均在乳管镜下放置定位针，根据定位进行手术，将乳管镜结果、手术情况、病理结果进行总结分析。结果24例病人中术后病理证实病变21例（875%），其中导管内乳头状瘤16例，纤维囊性乳腺病2例，导管内癌2 例，导管浸润癌1例。结论乳管镜下放置定位针有助于确定未扪及肿块的病变乳管和乳管内占位性病变位置，有利于提高早期乳腺癌的检出率，准确进行手术切除。

Application of localization needles under fiberoptic ductoscopy to the operation of intraductal space occupying lesions without palpable massYUAN Zhu,QU Xiang,ZHANG Zhongtao,et al.Department of General Surgery,Beijing Friendship Hospital Affiliated to Capital University of Medical Sciences,Beijing 100050,China Corresponding author：ZHANG Zhongtao,Email:zhangzht@medmail.com.cn AbstractObjectiveTo evaluate the value of localization needles under fiberoptic ductoscopy (FDS) for localizing intraductal space occupying lesions without palpable mass.MethodsNintytwo patients with nipple discharge accepted 117 cases of fiberoptic ductoscopy examination from August 2006 to March 2008 at Beijing Friendship Hospital. By the localization needles system under FDS,the intraductal space occupying lesions with unpalpable mass in 24 patients were localized and excised. FDS diagnosis,operation and pathologic diagnosis were analyzed retrospectively.ResultsTwenty-one of 24 patients with intraductal space occupying lesions were pathologically diagnosed (875%).Intraductal papilloma and galactocele were found in 16 patients and 2 patients respectively.Intraductal cancer and invasive duct cancer were found in 2 patients and 1 patient respectively.ConclusionApplication of localization needles under FDS can detect intraductal space occupying lesions early and locate accurate site,which is favorable to improve the diagnosis of early breast cancer and successful rate of operation.