中国实用外科杂志

中国实用外科杂志

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结直肠癌肝转移的转化治疗

王    崑，邢宝才   

  1. 北京大学肿瘤医院暨北京市肿瘤防治研究所肝胆外一科  恶性肿瘤发病机制及转化研究教育部重点实验室，北京 100142
  • 出版日期:2016-04-01 发布日期:2016-03-29

  • Online:2016-04-01 Published:2016-03-29

摘要：

对结直肠癌肝转移来说，手术是惟一的治愈手段。但80%的病人初始是不可切除的，将不可切除肝转移转化为可切除是提高结直肠癌总体存活率的关键。目前常用的转化手段有全身化疗（包括单纯化疗、化疗联合靶向药物等）、肝动脉灌注（HAI）、射频消融（RFA）、联合门静脉结扎或栓塞的分期肝切除、联合肝脏分隔及门静脉结扎的二步肝切除等。了解各种转化治疗的有效率和适应证是选择合适治疗的前提。

关键词: 结直肠癌, 肝转移, 不可切除, 转化

Abstract:

Conversion therapy for unresectable colorectal liver metastases        WANG Kun, XING Bao-cai. Hepatobiliary and Pancreatic Surgery Unit I, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China
Corresponding author: XING Bao-cai，E-mail: xingbaocai88@ sina.com
Abstract    For colorectal liver metastases (CRLM), surgery is the only curable treatment. However, 80% of CRLM is initial unresectable. How to transform patients with unresectable CRLM to resectable is the key to improve the overall survival of colorectal cancer. Strategies for conversion include systemic chemotherapy including target therapy, hepatic arterial infusion (HAI), radiofrequency ablation (RFA), portal vein embolization or ligation (PVE/PVL), associating liver partition with portal vein ligation for staged hepatectomy (ALPPS). Understanding the response rate and indications of various strategies is the prerequisite for the selection of appropriate treatment.

Key words: colorectal cancer, liver metastasis, unresectable, conversion