中国实用外科杂志 ›› 2022, Vol. 42 ›› Issue (08): 953-957.DOI: 10.19538/j.cjps.issn1005-2208.2022.08.20

• 文献综述 • 上一篇    下一篇

内脏脂肪组织与结直肠癌发病风险及预后关系研究进展

冯哲文,田名伟,寇天阔,李东明,宋建宁,杨    鋆,杨盈赤,张忠涛   

  1. 首都医科大学附属北京友谊医院,北京100050
  • 出版日期:2022-08-01 发布日期:2022-08-15

  • Online:2022-08-01 Published:2022-08-15

摘要: 内脏脂肪组织比皮下脂肪组织有更高的代谢活性,促进胰岛素抵抗和分泌促炎细胞因子,可视为一个内分泌和旁分泌器官。大量的内脏脂肪组织阻挡手术视野,促进胰岛素抵抗和炎症通路,直接或间接影响结直肠癌的发生风险、术后并发症发生率、生存时间以及辅助治疗疗效。外科医生通过健康体检和术前检查评估内脏脂肪组织数量,有助于向病人提供更适合的预防建议、手术规划以及预后预测。

关键词: 内脏脂肪组织, 内脏型肥胖, 结直肠癌

Abstract: Advances in the association between visceral adipose tissue and risk and prognosis of colorectal cancer                        FENG Zhe-wen, TIAN Ming-wei, KOU Tian-kuo, et al.Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Corresponding author: ZHANG Zhong-tao,E-mail:zhangzht@
ccmu.edu.cn
Abstract    Visceral adipose tissue has higher metabolic activity than subcutaneous adipose tissue. Visceral adipose tissue promotes insulin resistance and secretes pro-inflammatory cytokines, which can be regarded as an endocrine and paracrine organ. A large amount of visceral adipose tissue blocks the surgical field, and promotes insulin resistance and inflammatory pathways, which affects the risk of colorectal cancer, the incidence of postoperative complications, survival time and the efficacy of adjuvant therapy, directly or indirectly. It helps surgeons provide more appropriate preventive advice, surgical planning and prognosis prediction by evaluating the amount of visceral adipose tissue from physical examination and preoperative examination.

Key words: visceral adipose tissue, visceral obesity, colorectal cancer