中国实用外科杂志

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结直肠癌肝转移的微创及介入治疗

张航瑜,朱    旭,郭建海   

  1. 北京大学临床肿瘤学院介入科  北京肿瘤医院暨北京市肿瘤防治研究所  恶性肿瘤发病机制及转化研究教育部重点实验室,北京 100142
  • 出版日期:2016-04-01 发布日期:2016-03-29

  • Online:2016-04-01 Published:2016-03-29

摘要:

与外科手术和全身化疗相比,微创介入治疗具有可重复性、微创性和更高的局部控制率。随着技术的发展及临床证据的不断更新,微创介入治疗在多学科综合治疗协作组(MDT)中得到了越来越多的认可。经血管介入治疗因其通过肿瘤供血动脉给药,不仅提高了肿瘤的局部控制效果,而且减少了化疗药物全身的毒副反应,作为全身治疗失败后的二线治疗已经得到指南的推荐。非血管微创治疗作为结直肠癌肝转移综合治疗的必要补充,合理选择适应证可以获得外科手术和全身化疗无可比拟的疗效。但选择这些局部治疗方法时必须考虑全身治疗情况。

关键词: 结直肠癌, 肝转移, 消融, 动脉化疗栓塞

Abstract:

Minimally invasive interventional therapy of colorectal liver metastases        ZHANG Hang-yu, ZHU Xu, GUO Jian-hai. Department of Interventional Therapy, Peking University School of Oncology, Beijing Cancer Hospital & Institute; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing 100142, China
Corresponding author:ZHU Xu,E-mail:drzhuxu@163.com
Abstract    Compared with systemic chemotherapy and surgery, minimally invasive interventional therapy has the advantages of repeatable, minimally invasive and high local control rate. With the development of technology and the update of clinical evidence, minimally invasive interventional therapy in the multidisciplinary team (MDT) has gain more acceptance.For the tumor feeding artery administration, interventional treatment via the vascular as a second-line treatment after systemic treatment failure has been recommended by the Guide. It can not only improve the tumor local control effect, but also reduce the toxicity of chemotherapy drugs. Non vascular minimally invasive treatment as a necessary complement to the comprehensive treatment of colorectal liver metastases, the reasonable choice of indications can obtain unparalleled curative effect compared with systemic chemotherapy and surgery. However , systemic treatment must be considered when making the choice of the local treatment methods.

Key words: colorectal cancer, liver metastases, ablation, tansarterial chemoembolization