关键词: 局部进展期甲状腺癌, 预后, 评价

Abstract: Prognosis evaluation of locally advanced thyroid cancer            ZHANG Hao, CHANG  Yu-ang. Department of Thyroid Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
Corresponding author: ZHANG Hao, E-mail:haozhang@cmu.edu.cn
Abstract    Locally advanced thyroid cancer (LATC) is one of the leading causes of death and postoperative recurrence in thyroid cancer patients. The main methods to evaluate the prognosis of LATC are TNM staging and American Thyroid Society (ATA) risk stratification for recurrence. When LATC invaded the recurrent laryngeal nerve, the risk of tumor recurrence was higher, but there was no effect on survival time. LATC invades the trachea, larynx, esophagus, neck, and upper mediastinal vessels, judged the impact on prognosis according to the specific degree of invasion. Synergetic mutations of BRAFV600E and TERT promoters are associated with aggressive clinicopathologic features and an increased risk of recurrence and mortality and may help to predict aggressive behavior of LATC and to assist in clinical decision-making. The establishment of a more accurate prognosis evaluation system for clinical and molecular markers of LATC will undoubtedly improve the efficacy of LATC surgery and benefit patients.

Key words: locally advanced thyroid cancer, prognosis, evaluation