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从国内外指南分析局部进展期甲状腺癌外科治疗策略

程若川,彭    颖   

  1. 昆明医科大学第一附属医院甲状腺疾病诊治中心,云南昆明650032
  • 出版日期:2023-08-01

  • Online:2023-08-01

摘要: 局部进展期甲状腺癌(TC)可明显侵犯周围重要结构,手术范围广,涉及重要器官的切除和重建,手术创伤及手术风险较大,并发症发生率较高。目前各版国内外指南与专家共识对于局部进展期TC的标准治疗方案仍然是手术为主,辅以促甲状腺激素(TSH)抑制、放射性碘(RAI)治疗、外放射及靶向治疗等。而在临床实践工作中,临床医生更多基于自身经验选择诊疗方案并未达成有效共识。为局部进展期的病人提供个性化的治疗选择,应以进一步提高切除率,减小手术风险,降低术后并发症发生率和病死率,延长生存期,保障生活质量为重点,不可“一刀切”地彻底放弃治疗或者不计后果地盲目手术;此外,若能进一步建立完善我国局部进展期TC人群的登记随访系统及质量控制体系,将可积累大量真实的临床实践数据从而形成有效的循证医学证据,在今后逐渐达成各国主流学者完全认同与接受的国际化统一指南,造福病人。

关键词: 局部进展期甲状腺癌, 外科治疗, 淋巴结清扫, 指南

Abstract: The surgical treatment strategy of locally advanced thyroid cancer  analyzed from domestic and foreign guidelines        CHENG Ruo-chuan, PENG Ying. Department of Thyroid Surgery, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
Corresponding author:CHENG Ruo-chuan,E-mail:cruochuan@
foxmail.com
Abstract    Locally advanced thyroid tumors (TC) can obviously invade the surrounding important structures, and the surgical scope is wide, involving the resection and reconstruction of vital organs, and the surgical trauma and risk are relatively high, and the incidence of complications is relatively high. At present, the standard treatment plan for locally advanced TC) is still mainly surgery, supplemented by TSH inhibition, radioactive iodine (RAI) therapy, external radiation, and targeted therapy. However, in clinical practice, most clinicians choose diagnosis and treatment plans based on their own experience without reaching an effective consensus. To provide personalized treatment options for locally advanced patients, the focus should be on further improving the resection rate, reducing the risk of surgery, reducing the incidence of postoperative complications and mortality, prolonging the survival period, and ensuring the quality of life, and it is not possible to completely abandon treatment or reckless blind surgery. In addition, if we can further establish and improve the registration and follow-up system and quality control system of the local advanced TC population in China, a large number of real clinical practice data will be accumulated to form effective evidence-based medical evidence, and international unified guidelines fully recognized and accepted by mainstream scholars in the future will be gradually reached for the benefit of patients.

Key words: local advanced thyroid tumor, surgical treatment, lymph node dissection, guideline