Abstract: The loss of multiple teeth in the maxillary anterior region often brings challenges to implantation for insufficient restorative space and compromised aesthetic outcomes due to hard and soft tissue defects，adjacent tooth displacement，and abnormal overbite/overjet. This article presents a case of multiple missing teeth in the aesthetic zone of the maxillary anterior region，complicated by periodontitis，malocclusion，and unfavorable adjacent tooth conditions. Through detailed condition analysis and careful treatment planning，a staged therapeutic approach was implemented，including initial periodontal therapy to control inflammation，orthodontic treatment to improve occlusion and create adequate restorative space，as well as simultaneous guided bone regeneration during implant placement to establish hard tissue foundation and restore contour. Ultimately，implant-supported prostheses were used to restore the completeness of the dentition，significantly improving both aesthetic effect and function. This case highlights the critical role of multidisciplinary comprehensive therapy in managing dentition defect in the maxillary anterior region，offering a systematic clinical framework and reference for the clinical management of similar cases.

Key words: implant restoration, anterior aesthetics, guided bone regeneration, dentition defect, periodontitis, malocclusion, multidisciplinary treatment

摘要： 上前牙区多牙缺失常因软硬组织缺损、邻牙移位和异常覆𬌗覆盖等，造成修复空间不足、美学效果欠佳等问题，为种植修复带来挑战。文章展示1例伴牙周炎和错𬌗畸形且邻牙条件不良的上前牙美学区多牙缺失病例，经详细的病情分析和缜密的方案制定，按照序列治疗程序完成系统治疗，包括牙周基础治疗控制炎症、正畸治疗改善咬合关系与修复空间、种植同期行引导性骨再生术创造硬组织条件与恢复轮廓，以及最终通过种植修复恢复牙列完整性，显著改善了美学效果与功能。该病例体现了多学科综合治疗在上前牙区牙列缺损修复中的关键作用，为类似病例的临床处理提供系统性的诊疗思路与参考依据。

关键词: 种植修复, 前牙美学, 引导性骨再生, 牙列缺损, 牙周炎, 错??畸形, 多学科治疗