中国实用口腔科杂志

中国实用口腔科杂志 ›› 2010, Vol. 3 ›› Issue (04): 223-225.

• 论著 • 上一篇    下一篇

口腔鳞状细胞癌组织中STAT3的表达及意义研究

  

  1. 山西医科大学口腔医学系，太原  030001
  • 收稿日期:2010-02-21 修回日期:2010-03-22 出版日期:2010-04-15 发布日期:2010-05-11

  • Received:2010-02-21 Revised:2010-03-22 Online:2010-04-15 Published:2010-05-11

摘要：

目的    研究口腔鳞状细胞癌（OSCC）组织中细胞信号传导和转录激活因子（STAT3）的表达及意义。方法    应用免疫组织化学EnVosion法，检测山西医科大学第一医院病理科2005年1月至2009年12月存档的50例OSCC病理组织标本与10例正常口腔黏膜组织中STAT3蛋白的表达水平，并进行统计学分析。结果    OSCC标本中STAT3主要表达在细胞浆，也有少量表达在细胞核。STAT3在OSCC标本中的阳性表达率为88.0%，明显高于在正常口腔黏膜组织中的表达率（10.0%），差异有统计学意义（P < 0.01）。STAT3表达与OSCC病理分级、临床分期和是否有淋巴结转移密切相关（P < 0.05）。结论    STAT3蛋白的异常表达与OSCC的发生、发展有密切的关系，可作为OSCC治疗和预后的辅助性指标。

关键词: 口腔鳞状细胞癌, STAT3, 免疫组织化学

Abstract:

Objective    To investigate the expression and significance of STAT3 in oral squamous cell carcinoma（OSCC）. Method    A immunohistochemistry method， EnVosion，was employed to test the manifesting levels of STAT3 in pathological slices of 50 OSCC cases and 10 normal cases， and the results were used to make statistical analysis. Results    In 50 OSCC cases， STAT3 was mainly manifested in cytoplasm， and a little is manifested in karyon. The positive manifesting rates of STAT3 in the samples was 88.0%， which was notably higher than the manifesting rate of 10.0% in normal oral mucous membrane. The difference was of statistical significance （P < 0.01）. The manifestation of STAT3 was correlated with the different pathological grades， clinical phases and lymph node metastasis （P < 0.05）. Conclusion    The abnormal manifestation of STAT3 is closely related to the occurrence and development of OSCC. Therefore，it can be used as subsidiary index for OSCC treatment and prognosis.

Key words: oral squamous cell carcinoma／OSCC； STAT3； immunohistochemistry