中国实用口腔科杂志

中国实用口腔科杂志

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Kank1在口腔鳞状细胞癌中的表达及意义

薛晓寒1，周阳1，李琛1，高旭2，魏秀峰1   

  1. 1.吉林大学口腔医学院口腔黏膜科，吉林省牙发育及颌骨重塑与再生重点实验室，吉林  长春  130021；2.青岛市口腔医院牙体牙髓科，山东  青岛  266001
  • 出版日期:2019-12-15 发布日期:2020-01-02
  • 基金资助:
    国家自然科学基金青年科学基金（81500820）；吉林省科技厅资助课题（20160101052JC）；吉林大学白求恩医学部青年基金（2015431）

  • Online:2019-12-15 Published:2020-01-02

摘要： 目的　研究Kank1在口腔鳞状细胞癌（OSCC）中的表达及意义。方法　使用免疫组化SP法分别检测Kank1在60例OSCC组织及20例正常口腔黏膜（normal oral mucosa，NOM）中的表达情况，并结合OSCC患者的临床相关资料，研究Kank1与OSCC发生发展的关系。结果　Kank1在OSCC组织中的高表达率为55%，而在NOM中的高表达率为100%，两者比较差异有统计学意义（χ2 = 13.585，P＜0.001）；Kank1的表达与OSCC的分化程度有关联，随着分化程度的降低，Kank1的表达也呈下降趋势（P < 0.05）；Kank1在有淋巴结转移的OSCC患者癌组织中的表达明显低于无淋巴结转移的患者（P＜0.05），但与患者的性别、年龄无明显关联（P＞0.05）。结论　Kank1可能参与了OSCC的发生发展及转移过程。

关键词: Kank1, 口腔鳞状细胞癌, 免疫组织化学

Abstract: Objective　To study the expression and significance of Kank1 protein in oral squamous cell carcinoma （OSCC）. Methods　Immunohistochemical SP method was used to detect Kank1 expression in oral mucosa of 60 patients with OSCC and 20 normal mucosa tissues. The correlation between Kank1 and OSCC was studied based on clinical data of OSCC patients. Results　The high expression rate of Kank1 in OSCC was 55%，while it was 100% in normal oral mucosa，which was significantly higher than that of Kank1 in OSCC （χ2 = 13.585，P＜0.001）. The expression of Kank1 had a connection with the differentiation of OSCC. With the decline of differentiation degree，Kank1 expression also showed a decreased trend （P＜0.05）. Kank1 expression in patients with lymph node metastasis was significantly lower than that in OSCC without lymph node metastasis （P＜0.05），but there was no significant correlation between Kank1 expression and gender or age of patients （P＞0.05）. Conclusion　Kank1 may be involved in the occurrence，development and metastasis of OSCC.

Key words: Kank1, oral squamous cell carcinoma, immunohistochemistry