关键词: 再矿化, 牙本质, 合成多肽, 继发龋

Abstract: Secondary caries is the most prevalent reason for tooth restoration failures，accounting for 34% of all failures of resin-based dental materials. Demineralized dentin remineralization and prevention of collagen fiber hydrolysis of dentin to maintain the integrity and airtightness of the bonding interface are effective strategies for the prevention of secondary caries. With studies on dentin remineralization and non-collagenous proteins deepening，finding and designing peptides possessing mineralizing or multifunctional domains to simulate the function of natural non-collagenous proteins to achieve dentin biomimetic remineralization has become a research hotspot. This paper presents a review on the research progress in the role of synthetic peptides in the field of dentin remineralization，with the aim of improving the application of synthetic peptides and providing new ideas for promoting dentin remineralization and preventing secondary caries.

Key words: remineralization, dentin, synthetic peptides, secondary caries