关键词: 牙本质颗粒, 上颌窦底提升术, 骨再生

Abstract: Objective    To investigate the clinical effect of autologous dentin particles applied in maxillary sinus floor elevation. Methods    A total of 22 patients（35 implants）who were scheduled for lateral window maxillary sinus floor elevation with simultaneous implant insertion at the Affiliated Stomatological Hospital of School of Stomatology，Dalian Medical University，from September 2021 to February 2023，were recruited. The patients were randomly assigned into the dentin particle group（10 patients，17 implants）and the Bio-Oss group（12 patients，18 implants）via the random number table method. During the surgery of sinus floor elevation，autologous dentin particles and Bio-Oss were respectively grafted and implants were placed concurrently. The alveolar bone height，volume and density of bone graft materials，degree of swelling，pain level，implant survival rate，incidence of complications，and patient satisfaction were compared between the two groups. Results    Compared with the immediate post-operative stage，at 6 months after surgery，the alveolar bone height in the dentin particle group and the Bio-Oss group decreased by（0.84 ± 0.13）mm and（0.73 ± 0.13）mm respectively，the volume of bone graft materials decreased by（10.48 ± 4.26）mm³ and（12.18 ± 4.59）mm³ respectively，and the density of bone graft materials（CT value）increased by（169.00 ± 65.11）HU and（140.08 ± 58.33）HU respectively. All these differences were statistically significant（P < 0.05）. However，there were no statistically significant differences in the reduction of alveolar bone height，the reduction of the volume of bone graft materials or the increase of density between the two groups（P > 0.05）. Also，the differences between the two groups in the level of swelling and pain were not statistically significant at 2 weeks after surgery（all P > 0.05）. The incidence of maxillary sinus mucosa perforation in the dentin particle group and the Bio-Oss group was 10.0%（1/10）and 16.7%（2/12）respectively，the incidence of peri-implantitis in the two groups was 0.0%（0/17）and 11.1%（2/18）respectively，and the implant survival rate in both groups was 100%；there were no statistically significant differences（all P > 0.05）. The percentage of patient satisfaction in the dentin particle group was higher than that in the Bio-Oss group，and the difference was statistically significant（Z = 2.293，P = 0.022）. Conclusion    Favorable bone regeneration outcomes and clinical effectiveness can be achieved by application of autologous dentin particles in lateral window maxillary sinus floor elevation，and there is a higher level of patient satisfaction.

Key words: dentin particles, maxillary sinus floor elevation, bone regeneration