关键词: 骨免疫调节, 巨噬细胞, 骨整合, 表面改性, 血管生成

Abstract: Peri-implant tissue repair is an important factor that affects the success rate of the implant. At present，osteoimmunomodulation mediated by macrophages is one of the research hotspots of implantation，which focuses on promoting angiogenesis and accelerating bone remodeling. Implant surface treatment affects the polarization phenotype of macrophages both adhering on the surface of the implant and in the peri-implant inflammatory microenvironment，thereby affecting early soft tissue healing and late osteogenesis after implant surgery. This article reviews the effects of different implant surface treatments on the polarization of macrophages and tissue repair mediated by them，aiming at finding the best opportunity and strategy for osteoimmunomodulation.

Key words: osteoimmunomodulation, macrophage, osseointegration, surface modification, angiogenesis