关键词: 巨噬细胞, 生物材料, 矿化胶原, 异物反应

Abstract:

Biomaterials are widely used in prosthetic and regenerative medicine. Biomaterials can recover the physiological functions of damaged tissue through replacement or regeneration. Biomimetic mineralized collagen is a composite material possessing the same chemical compositions and microstructures with the natural bone tissue. It has good biocompatibility， biodegradability， osteoconduction and osteoinductivity and has good potential applications in terms of repairing bone defect and promoting new bone formation. Macrophages are important components of the immune system and they play an important role in maintaining the homeostasis， immune surveilance， the progression of disease and tissue reconstruction. Any biomaterials will lead to a foreign body reaction after they are implanted in the body. Macrophages are important in foreign body reactions. In this paper， we will summarize the relationship between biomaterials and macrophages.

Key words: macrophage, biomaterial, mineralized collagen, foreign body reaction