关键词: 骨质疏松症, 骨整合, 种植体, 动物模型

Abstract: Osteoporosis is a metabolic disease with decreased bone mass，decreased bone mineral density（BMD）and increased bone fragility. The deteriorated nature and mechanical properties lead to implant failure. Since osteoporosis mostly happens in elderly people，who are at high risk of tooth loss and osteoarticular diseases（OAD），there exists great demand of endosteal implant treatment like tooth implant and prosthetic replacement for joint. The way to enhance implant integration and stability in osteoporotic bone has been extensively investigated. Due to the pathological characteristics of osteoporosis including accelerated bone resorption and insufficient new bone formation，previous studies have mainly aimed at therapies suppressing bone resorption or promoting bone formation，including drugs，biological factors，implant surface modification，stem cell therapy and so on. This article aims to review the current research progress in options to enhance implant osseointegration in osteoporotic models. 

Key words: osteoporosis, osseointegration, implant, animal model