关键词: 牙周病, 肿瘤, 牙龈卟啉单胞菌, 具核梭杆菌

Abstract: Periodontal disease is a common chronic infectious disease that results from the interaction of multiple risk factors including plaque biofilm，environment，genetics and epigenomics. In recent years，more and more studies have found a close association between periodontal disease and malignancies. This article reviews the current epidemiological research status of periodontal disease associated with oral cancer，gastric cancer，colorectal cancer，pancreatic cancer，lung cancer，breast cancer and prostate cancer，as well as the pathogenic mechanism of periodontal disease in relation to malignancy，in order to provide a new idea for the early prevention and treatment and research of the diseases.

Key words: periodontal disease, tumor, Porphyromonas gingivalis, Fusobacterium nucleatum