关键词: 光动力疗法, 免疫, 口腔肿瘤, 炎症, 组织再生

Abstract: Photodynamic therapy（PDT）has developed rapidly in clinical application and has broad application prospects in the treatment of oral tumors，oral mucosal diseases，pulp and periodontal diseases and tissue regeneration. Immune regulation plays an important role in photodynamic therapy. Photodynamic therapy can induce cell apoptosis or directly destroy cells，expose antigen substances，and then stimulate the proliferation and activation of immune cells and release inflammatory cytokines，so as to destroy the lesion tissues and inhibit tumor proliferation. It can regulate local inflammatory process by changing vascular permeability，promote anti-inflammatory polarization of immune cells，and reduce inflammatory cell infiltration. It can indirectly promote tissue regeneration by changing the secretion pattern of local cytokines，or directly target immune cells to induce proliferation or differentiation of endothelial，cartilage and fibroblast cells. This article reviews the immunomodulatory effects of photodynamic therapy and its application direction in stomatology. 

Key words: photodynamic therapy, immune, oral tumor, inflammation, tissue regeneration