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02 November 2021, Volume 37 Issue 11 Previous Issue    Next Issue

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Prediction and early warning of pre-eclampsia.  GU Wei-rong, LI Xiao-tian 2021, 37(11): 1087-1092.  DOI: 10.19538/j.fk2021110103 Abstract ( )   Pre-eclampsia can directly affect the pregnant outcome and even the long-term health of mother and child.Maternal risk factors，mean arterial pressure，uterine artery Doppler index and serum biochemical markers are used to predict pre-eclampsia，and its combination with screening in early pregnancy is of high predictive value.It helps to give proper treatment to attach importance to the early warning information of pre-eclampsia and make timely diagnosis，and to predict the severity of the disease and the adverse outcome of pregnancy，including deciding the timing of delivery，and ultimately improving the pregnant outcome.

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Prediction and early warning of fetal growth restriction. QIAO Juan, CHEN Rui-xin, QI Hong-bo. 2021, 37(11): 1092-1095.  DOI: 10.19538/j.fk2021110104 Abstract ( )   Fetal growth restriction is the second leading cause of perinatal death, but its treatment is limited, so the prediction and risk assessment of fetal growth restriction has always been a hot spot in clinical and research work.In recent years, some high-quality researches in maternal risk factors of fetal growth restriction，ultrasonic doppler flow, magnetic resonance imaging, serological biomarkers and multi-parameter prediction assessment have made certain progress. We summarize and analyze these reaserches based on the China expert consensus of FGR（2019 Edition），hoping to provide some references for the prediction and early warning  of FGR.

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Prediction of preterm birth. WANG Jing, CHEN Wei, WANG Zi-lian 2021, 37(11): 1095-1101.  DOI: 10.19538/j.fk2021110105 Abstract ( )   In China，preterm birth （PTB） is defined as delivery with gestational age reaching 28 weeks but less than 37 weeks. Currently，several guidelines have recommended that a history of miscarriage or preterm birth and the cervical length（CL）of a second trimester ≤25 mm be used to predict preterm birth. In recent years，the biochemical molecular markers such as fetal fibronectin，phosphorylated insulin-like growth factor binding protein 1，placental alpha micro-globulin 1，inflammatory cytokines，cervical angle and cervical hardness used to predict preterm birth have gained attention of the researchers.This article will review the existing methods of preterm prediction and its application value，so as to provide reference for clinical practice.

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Prediction and early warning of postpartum hemorrhage. CHEN Peng, LIU Xing-hui 2021, 37(11): 1101-1105.  DOI: 10.19538/j.fk2021110106 Abstract ( )   Although the maternal mortality has decreased year by year，postpartum hemorrhage（PPH）is still the main reason for maternal death. The risk assessment of PPH includes recognition of high risks and the application of the assessment tools.The existing methods have their limitations，and it's necessary to use the bleeding volume，speed of blood loss，vital signs and shock index for the early warning of postpartum hemorrhage in real time，and we can establish the early warning system with these indexes.

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Application value of molecular biomarkers in prenatal diagnosis of placenta accreta spectrum disorders. LI Ze-li, CHEN Lian, ZHAO Yang-yu 2021, 37(11): 1105-1108.  DOI: 10.19538/j.fk2021110107 Abstract ( )   The commonly used prenatal diagnosis methods for placenta accreta spectrum disorders are mainly clinical risk factors combined with imaging examination，but its accuracy is somewhat subjective. With the deeper study on the pathogenesis of the diseases，the possibility of serological markers as an adjuvant examination is gradually recognized. This review intends to summarize the current researches on potential biomarkers for placenta accreta spectrum disorders，and explore their significance in prenatal diagnosis and their application values.

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Prediction of stillbirths and management of high-risk population. WEI Xing, SUN Lu-ming 2021, 37(11): 1108-1112.  DOI: 10.19538/j.fk2021110108 Abstract ( )   Stillbirth is the final outcome of maternal，fetal and placental diseases under various risk factors. The predictive value of stillbirths due to impaired placentation using a combination of maternal factors，fetal biometry，uterine artery Doppler and maternal serum placenta growth factor during the first and  second trimester was high，but it is limited  for term stillbirths.Correct identification of high-risk factors of stillbirth，strengthening the management of preconception and pregnancy in high-risk groups，using various prenatal monitoring methods effectively and timely delivery can  reduce the occurrence of stillbirth.

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Early warning of thyroid storm during pregnancy. DONG Xin, LI Xue-lan 2021, 37(11): 1112-1115.  DOI: 10.19538/j.fk2021110109 Abstract ( )   Thyroid storm is a kind of endocrine emergency，which is characterized by rapid deterioration. Pregnancy with thyroid storm has the characteristics of low incidence and high mortality，which brings great challenge to clinical diagnosis and treatment. The occurrence of thyroid storm has clear incentives，and the diagnosis is mostly based on clinical manifestations. At present，there are several predictive models for the diagnosis of thyroid storm，but each has its advantages and disadvantages. In clinical work，a comprehensive analysis is required to strive for early and timely diagnosis，and to initiate accurate and effective treatment as soon as possible and avoid inappropriate medication，in order to improve perinatal outcome.

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Prediction and early warning of ketoacidosis during pregnancy. HANG Wei, XU Xian-ming 2021, 37(11): 1115-1118.  DOI: 10.19538/j.fk2021110110 Abstract ( )   Diabetic ketoacidosis（DKA） in pregnancy is a rare but potential life-threatening condition for the mother and the fetus. Although DKA is more common in patients with type 1 diabetes，it has been reported too in those with type 2 diabetes as well as gestational diabetes. Early recognition and diagnosis is of great significance in improving maternal and fetal outcomes. This article will provide the reader with information regarding the pathophysiology underlying DKA，the influence on the mother and the fetus，the precipitating factors，the predictors and the early warning signs and prediction models of DKA.