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    02 October 2014, Volume 30 Issue 10 Previous Issue    Next Issue

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    Prediction value of maternal circulation factors and Doppler ultrasonography for preeclampsia.
    YE Yun-zhen, ZHOU Qiong-jie, LI Xiao-tian.
    2014, 30(10): 744-748.  DOI: 10.7504/fk2014090103
    Abstract ( )   PDF (921KB) ( )  

    Abstract: Preeclampsia remains a leading cause of maternal and fetal mortality. Early prediction of the occurrence, development and adverse pregnancy outcomes of preeclampsia is of great significance. Maternal circulation factors in the first two trimesters and Doppler ultrasonography are potential strategies to the prediction of preeclampsia.

    The early intervention and preventive value of low-dose aspirin in preeclampsia.
    HUANG He,CHEN Qian.
    2014, 30(10): 748-750.  DOI: 10.7504/fk2014090104
    Abstract ( )   PDF (891KB) ( )  

    Abstract: Preeclampsia is a common obstetric disorder with high perinatal mortality and iatrogenic preterm birth. There is extensive evidence from randomized studies that modulating the impaired PGI2/TXA2 ratio in pathogenesis of preeclampsia by prophylactic administration of low-dose aspirin appears to be associated with a reduction in the prevalence of preeclampsia. It is recommended to initiate administration of daily low-dose aspirin beginning in the late first trimester for women at risk to prevent preeclampsia while not inducing maternal and fetal hemorrhage.

    Role of low-molecular-weight heparin in the early intervention of severe preeclampsia.
    DU Pei-li,CHEN Dun-jin.
    2014, 30(10): 750-752.  DOI: 10.7504/fk2014090105
    Abstract ( )   PDF (874KB) ( )  

    Abstract: Severe preeclampsia is a serious harm disease during pregnancy, often accompanied by serious maternal and fetal complications, leading to adverse pregnancy outcomes. Low-molecular-weight heparin, known for anticoagulation, anti-inflammation and protecting vascular endothelial, can play its role in the pathological and physiological process of severe preeclampsia in many ways,and it also can be used as an early intervention treatment for severe preeclampsia, so it has important significance in reducing maternal complications and slowing the progression of the disease.

    Further pregnancy in preeclampsia.
    SHI Lin,LIU Xing-hui.
    2014, 30(10): 753-755.  DOI: 10.7504/fk2014090106
    Abstract ( )   PDF (872KB) ( )  

    Abstract: The patients with preeclampsia history are high-risk population of recurrent preeclampsia. They face many problems at further pregnancy and should be paid more attention. Early prevention, early detection and early treatment are needed.

    Early clinical interventions for prevention of recurrence of preeclampsia.
    YANG Zi, LI Wei.
    2014, 30(10): 755-758.  DOI: 10.7504/fk2014090107
    Abstract ( )   PDF (887KB) ( )  

    Abstract: A history of pre-eclampsia is an independent risk factor for recurrence of preeclampsia. Recurrence of preeclampsia has more severe clinical outcomes. Recurrence of the disease is affected by multiple factors, but prevention is the key. Comprehensive maternal risk assessment, strengthening individualized prenatal care, early identification of risk factors,and implementation of early corresponding intervention are the key to reducing or avoiding in the recurrence of preeclampsia.

    Early identification and intervention of preeclampsia complicated by peripartum cardiomyopathy.
    LIN Jian-hua, ZHAO Wei-xiu.
    2014, 30(10): 759-761.  DOI: 10.7504/fk2014090108
    Abstract ( )   PDF (893KB) ( )  

    Abstract: There are same risk factors for preeclampsia and peripartum cardiomyopathy. These two pregnancy-associated diseases can either exist independently or coexist. Once these two diseases coexist, maternal and perinatal health would be seriously threatened. Therefore, the patients with preeclampsia,especially severe preeclampsia,should undergo echocardiography and other accessory examinations as soon as possible in order to identify early PPCM or cardiac dysfunction and manage them.

    Oxidative stress and antioxidant response in preeclampsia.
    LIU Jun-tao, SONG Ying-na.
    2014, 30(10): 761-764.  DOI: 10.7504/fk2014090109
    Abstract ( )   PDF (909KB) ( )  

    Abstract: With the higher OS status, many antioxidant systems have been shown to be upregulated or downregulated in the placenta and or the maternal circulation during PE. Such altered antioxidant response can lead to increased lipid peroxidation and can also affect signal transduction and enzymatic pathways related to eicosanoid synthesis. Based on the above mechanism, antioxidants might be important for the prevention of PE. But no statistically significant difference was found between women who received antioxidant treatment and women who received placebo for preeclampsia. Further prospective study is needed in this field.

    Diet and exercise intervention during pregnancy to prevent preelampsia.
    ZOU Li-ying, ZHANG Wei-yuan.
    2014, 30(10): 764-766.  DOI: 10.7504/fk2014090110
    Abstract ( )   PDF (873KB) ( )  

    Abstract: Hypertensive disorder complicating pregnancy is a severe gestational complication and may be connected with absence or excessive intake of nutrient substance and lack of movement. Diet and exercise intervention during pregnancy can prevent preelampsia early to some extent.

    The role of lipid intervention in early prevention of preeclampsia.
    YANG Yang,MENG Tao.
    2014, 30(10): 766-769.  DOI: 10.7504/fk2014090111
    Abstract ( )   PDF (900KB) ( )  

    Abstract: In order to maintain the pregnancy、 fetal growth and development, postpartum nursing and other special requirements, a certain amount of fat reserving during pregnancy is important. But the study showed that compared with normal pregnant women,the blood lipid level in patients with preeclampsia increases obviously. Dyslipidemia may cause the development of preeclampsia through oxidative stress, inflammatory reaction and so on,which damages vascular endothelial cell function.So early intervention and blood lipids control through diet and exercise intervention and necessary medication is necessary, and a reasonable diet and proper exercise during pregnancy plays an important role in the prevention of preeclampsia, but lipid-lowering drugs during pregnancy still needs a lot of evidence to confirm.

    Proteinuria value determination and hypoproteinemia in the diagnosis and treatment of preeclampsia.
    SUN Qian-qian,GU Hang.
    2014, 30(10): 769-771.  DOI: 10.7504/fk2014090112
    Abstract ( )   PDF (904KB) ( )  

    Abstract: For a long time, on the basis of early researches, proteinuria has been recognized as one of diagnostic criteria of preeclampsia. With the development of proteinuria, it became more and more important. But the research about the relation of proteinuria and preeclampsia has not ending, so now investigators have different opinions about this issue. In order to make it clear, trying to study this article was written based on guidelines and literature,the clinical significance of serum protein and the effect of hypoproteinemia on mothers and infants.

    Role of immune regulation in the early intervention of preeclampsia and its evaluation.
    FAN Yu-qin,LI Lei,WANG Xie-tong.
    2014, 30(10): 771-774.  DOI: 10.7504/fk2014090113
    Abstract ( )   PDF (908KB) ( )  

    Abstract: The occurrence of preeclampsia and immune disorders have certain relations. Abnormal immune tolerance of maternal-fetal interface makes invasive trophoblast cells decrease and uterine spiral arteries of "recast obstacles"occur, leading to the formation of pathological placenta.There are various autoimmune abnormalities,for example,antiphospholipid antibody interferes with blood clotting and anticlotting factors,resulting in clotting disorders and placental micro thrombosis,which leads to decreased placental perfusion volume.Preeclampsia early intervention measures include:with risk factors,for pre-edampsia for pregnant women start taking low-dose aspirin in the middle trimester,which has a better preventive effect. During early and metaphase trimester of pregnancy,low-molecular weight heparin therapy also has a certain effect.The effect of various immune treatment and oxidation treatment lack evidence of evidence-based medicine.

    The effects of tie2+-U937 on proliferation, angiogenesis and lymphangiogenesis of ovarian carcinoma.
    ZHU Qin-yi, WU Li, WU Xiao-li, WANG Kai, WANG Xi-peng.
    2014, 30(10): 775-779.  DOI: 10.7504/fk2014090114
    Abstract ( )  

    Abstract: Objective Aim to explore the effects of Tie2+-U937 cells on proliferation and its efftcts on angiogenesis and lymphangiogenesis of ovarian carcinoma in nude mice.Methods The ovarian carcinoma models were constructed between Janary 2013 and Fedruary 2014 in Shanghai Jiaotong University School of Medicine Human Tie2+-U937 cells and NC-U937 cells were cultured by transfection. Nude mice were injected with mix of human SKOV3ip1-luc cells and Tie2+-U937 cells or NC-U937 cells by 1:10 in the subcutaneous models and orthotopic models . SKOV3 cells were injected as control group. The proliferation time, tumor size, CD31 and LYVE-1 expression of ovarian carcinoma were detected.Results The results revealed that Tie2 led to an enhancement on tumor proliferation. In the subcutaneous models: Tie2 led to an enhancement on tumor proliferation, compared with U937 group and control group on the 8th day and 21st day. The tumor weights of different groups on the 21st day : Tie2 group(0.43±0.16)g, U937 group (0.18±0.04)g, control group (0.13±0.08)g(P<0.05).In the orthotopic models: Tie2 led to an enhancement on tumor proliferation, compared with U937 group and control group on the 14th day and 35th day. Tie2 group was illustrated the highest intratumoral CD31 and LYVE-1 expression level, as compared with the other groups (P<0.05). Conclusion Tie2+-U937 cells can promote ovarian carcinoma proliferation through angiogenesis and lymphangiogenesis in nude mice.

    Clinical study on the factors affecting the recurrence of preeclampsia.
    LI Wei, YANG Zi, WANG Hai-ling,HAN Yi-wei.
    2014, 30(10): 780-785.  DOI: 10.7504/fk2014090115
    Abstract ( )  

    Abstract: Objective To investigate the factors associated with recurrence of preeclampsia.Methods A retrospective study of 82 cases of preeclampsia history in Obstetric Department of Peking University Third Hospital from January 2009 to March 2014 was performed. Cases were divided into two groups: cases with preeclampsia history and recurrent preeclampsia in the subsequent pregnancy was RPE group ,while cases with preeclampsia history without recurrence in the subsequent pregnancy was NRPE group. The clinical data was analyzed in the two group. Results In the population studied, the incidence of preeclampsia was 6.6% (1182/17939);in those who have a history of preeclampsia , preeclampsia recurrence rate was 45.1% (37/82). Preeclampsia recurrence factors: the maternal foundation: in 82 patients with a history of preeclampsia , 43.9% (36/82) were combined with medical disease, in which 34.1% (28/82) were combined with chronic hypertension;in RPE group medical diseases combined accounted for 67.6% (35/37),chronic hypertension accounted for 54.1% (20/37) , both of which were significantly higher than NRPE group (P<0.001、P=0.001). Previous preeclampsia pregnancy: the highest systolic blood pressure (P=0.009) and maximum diastolic blood pressure (P = 0.004) of previous preeclampsia in RPE group were significantly higher than NRPE group; the proportion of previous severe hypertension in RPE group was significantly higher than in NRPE group (P=0.007). Prenatal care:the proportion of regular antenatal care in RPE group was significantly lower than that in NRPE group (P= 0.020); the proportion of regular antenatal care in tertiary hospital was significantly lower than NRPE group (P<0.001).Multivariate logistic regression analysis showed that patients with chronic hypertension (adjusted OR=7.00, 95% CI 2.27,21.52) and irregular prenatal care (adjusted OR=4.19, 95% CI 1.14,15.42) were independent risk factors of preeclampsia recurrence. Conclusion Chronic hypertension and irregular prenatal care are independent risk factors of preeclampsia recurrence. Maternal underlying disease is an important factor in preeclampsia morbidity and relapse.

    Epidemiological survey on placenta previa in seven regions of China.
    LI Qing*,WANG Zhi-jian*,YU Yan-hong*,GUO Sui-qun,GUO Xiao-ling,XIA Yu-ying,ZHANG Wei-yuan.
    2014, 30(10): 786-790.  DOI: 10.7504/fk2014090116
    Abstract ( )  

    Abstract: Objective To investigate prevalence,risk factors and mother and fetus outcomes of placenta previa in seven regions of China . Methods Data from 108049 single pregnant women in 39 different hospitals of seven regions in China from January 2011 to December 2011 were analyzed by cross section.The risk factors and mother and fetus outcomes of 1304 single pregnant women complicated with placenta previa were analysed. Results The overall incidence of placenta previa was 1.2%(1304/108049) in China. In addition,the incidence of placenta previa in different regions including northeast,north China,central China,east China,south China,southwest,northwest of China was different,which was 1.1%(184/16518), 0.8%(287/34852) ,0.5%(26/5541),1.3%(280/21562),1.0%(92/8828),3.6%(350/9686),and 0.8%

    Clinical study of risk factors of postpartum hemorrahge and risk evaluation system.
    YAN Jian-ying, HUANG Ke-hua, LIU Qing-min, HUANG Xiao-yan, XU Rong-li.
    2014, 30(10): 791-797.  DOI: 10.7504/fk2014090117
    Abstract ( )  

    Abstract: Objective To identify the risk factors of postpartum hemorrahge(PPH) and establish evaluation system and prediction equation for the risk of morbidity. Methods A case-control(1∶2) observational study was conducted.Totally 212 parturients with PPH, who presented to Fujian Maternity and Child Health Hospital for regular prenatal care and parturition from December 2008 to December 2009, were selected as the study group.The control group consisted of 424 health parturients at the same period.Univariate analysis was used for risk factors screening.Then,based on “predict-scale of postpartum hemorrahge” set by national PPH prevention cooperation,establish perfect “risk evaluation system of PPH”.Compare effectiveness between them by receiver-operating characteristics.Resaults Incidence of PPH was 3.07%, and 15.56% of them were severe PPH.The risk factors of PPH included age, parity,induced abortion,BMI in early pregnancy, uterine height,multiple pregnancy, PLT,placental previa,hypertensive disorders complicating pregnancy , hysteromyoma, fetal abdominal circumference, hydramnios, delivery way,uterine laceration of caesarean section,genital tract trauma, abnormal first stage,prolonged third stage, placental adherence or accrete and born weight.The risks of PPH increased significantly ,when total score ≥6 or antepartum score≥4.AUC of predict-scale used in this study was 0.657,and AUC of risk evaluation system was 0.805.Prediction equation for the risk of PPH was Z=1-1/[1+exp(-3.216+0.482×antepartum score +0.452×intrapartum and postpartum score)],or Z=1-1/[1+exp(-3.187+0.469×total score)].Conclusions  The happening of PPH has a close association with the fundamental factors of pregnant woman, fetus, complications, labor and so on.Women with total score ≥6 or antepartum score≥4 required close monitoring.The risk evaluation system is more efficient than the predict-scale for detecting PPH.

    The characteristics of abdominal wall endometriosis:meta-analysis and literature review.
    WU Zhen-zhen, GUO Yu-zhen.
    2014, 30(10): 802-806.  DOI: 10.7504/fk2014090119
    Abstract ( )  

    Abstract: Objective To discuss the characteristics of abdominal wall endometriosis (AWE). Methods According to the in and out standards,we located studies through the PubMed retrieval.Terms were: abdominal wall endometriosis, extrapelvic endometriosis, scar endometriosis, incisional endometriosis, inguinal endometriosis, umbilical endometriosis, ectopic endometriosis, cutaneous endometriosis, relations as "or";term limited was in the title or abstract;the deadline for publication was from 1980 to 2012.There were 31 studies located including 441 cases.We assessed quality of studies by using STATA10.0 statistical software. Results Cesarean section accounted for 63.04%(278/441cases),transabdominal hysterectomy 9.98% of cases (44/441cases),other operations 7.48%(33/441cases),and spontaneous cases 14.29%

    The freeze-all embryo strategy applied to ovarian high responders.
    DONG Meng, WEI Jing-zan,HE Li-xia, YANG Da-lei, ZHANG Wei, JIAO Jiao, WANG Xiu-xia.
    2014, 30(10): 807-811.  DOI: 10.7504/fk2014090120
    Abstract ( )  

    Abstract: Objective To compare implantation and pregnancy outcome between fresh embryo transfer (ET) cycles after ovarian stimulation and frozen–thawed embryo transfer (FET) cycles in high responders and to evaluate the effect of fresh ET on endometrial receptivity.Methods We retrospectively analyzed 582 patients with fresh ET (fresh group) and 167 patients with FET (cryopreservation group) between January 2011 and December 2013 from Shengjing Hospital of China Medical University.The two groups were compared for clinical pregnancy rate, biochemical loss rate, implanting rates, embryonic diapaus rate, ectopic pregnancy rate, miscarriage rate, ongoing pregnancy rates and multiple pregnancy rates.Results The clinical pregnancy rate, biochemical loss rate , implantationy rates and ongoing pregnancy rates were 42.44% ,7.22%, 28.27% and 34.19% in fresh ET cycles, compared with 69.46%, 2.99%,48.99% and 59.88% in FET cycles. The clinical pregnancy rate , biochemical loss rate,implantation rates ,ongoing pregnancy rates were significantly different between fresh ET and FET cycles (P<0.05).Conclusions The clinical pregnancy rate, implantation rates and ongoing pregnancy rates are significantly greater in the fresh embryos which are cryopreserved and then transferred in FET cycles in high responders. These results strongly suggest freeze-allembryo strategy can obtain a more ideal pregnancy outcome. Impaired endometrial receptivity apparently accounts for most implantation failures in the fresh group.

    The expression of OCT4 and AKT1 in ovarian serous tumor and their correlation with drug resistance of chemotherapy.
    SHI Cong*,WANG Min*,ZHU Yan-li, YAN Xiao-yu*.
    2014, 30(10): 812-816.  DOI: 10.7504/fk2014090121
    Abstract ( )  

    Abstract: Objective To study the expression of OCT4 and AKT1 in ovarian serous tumor and their correlation with drug resistance of chemotherapy.Methods From Shengjing Hospital of China Medical University between January 2004 and October 2010,67 cases of ovarian serous cystadenocarcinoma were selected(30 cases resistant,37 cases sensitive),10 cases of normal ovarian tissues,10 cases of ovarian benign cystadenoma and 10 cases of ovarian serous cystadenoma for test. The OCT4 and AKT1 were tested by immunohistochemistry. Results The positive rates of OCT4 in normal group, benign group, borderline group and malignant group were 0,40.00%,50.00% and 62.69%,the differences being significant(P=0.002); in drug resistance group and sensitive group they were 83.33%and 45.95%,the differences being significant(P=0.002). The positive rates of AKT1 in normal group, benign group, borderline group and malignant group were0,40.00%,70.00% and 62.69%,the differences being significant(P=0.001); in drug resistance group and sensitive group were they 76.67% and 51.35%,the differences being significant(P=0.033). The expression of OCT4 didn’t correlate with any clinicopathologic factors, but AKT1 correlated with clinical stage(P<0.05). A positive correlation was found between the expression of OCT4 and AKT1 in drug resistance group(r=0.388,P=0.034) but not in sensitive group(r=0.246,P=0.142). Conclusions OCT4 and AKT1 are probably involved in early carcinogenesis of ovarian serous cystadenocarcinoma and risk factors for drug resistance.

    Clinical application of birth ball in maternal self-efficacy intervention.
    YANG Li, DAI Li.
    2014, 30(10): 817-819.  DOI: 10.7504/fk2014090122
    Abstract ( )  

    Abstract: Objective To study effects of the birth ball in the self-efficacy interventions of primiparae. Methods Between Oct.2012 and Dec.2013, 200 normal primiparae from Shengjing Hospital of China Medical University were randomly divided into an observation group and a control group.Conventional obstetrical nursing was accepted by the observation group;besides,full-time midwives gave specialized guidance used for the birth ball to the observation group, and the observation group used the birth ball. Except that the birth ball is not used in the control group, other intervention measures are the same. The two groups of primiparae were assessed before and after the interventions by applying a common self-efficacy scale, and birth conditions of the two groups were observed. Results Compared with the control group,the pain tolerance of observation group was increased. The P value was less than 0.05 in the first birth process time of observation group(6.51±2.61),compared with the control group(8.48±3.00);the total birth process time of observation group(7.27±2.67),compared with the control group(9.34±3.14);the cesarean section rate of observation group(8%),compared with the control group(27%);the self-efficacy interventions of observation group(29.18±1.62),compared with the control group(26.49±1.15). Conclusion The birth ball could promote the self-efficacy of the primiparae, and also, the natural birth rate of the primiparae can be increased, the birth process is shortened, the cesarean section rate is reduced, and the satisfaction of the primiparae is enhanced.