Clinical study on the factors affecting the recurrence of preeclampsia.
LI Wei, YANG Zi, WANG Hai-ling，HAN Yi-wei.
Chinese Journal of Practical Gynecology and Obstetrics ›› 2014, Vol. 30 ›› Issue (10) : 780-785.
Clinical study on the factors affecting the recurrence of preeclampsia.
Abstract： Objective To investigate the factors associated with recurrence of preeclampsia.Methods A retrospective study of 82 cases of preeclampsia history in Obstetric Department of Peking University Third Hospital from January 2009 to March 2014 was performed. Cases were divided into two groups: cases with preeclampsia history and recurrent preeclampsia in the subsequent pregnancy was RPE group ,while cases with preeclampsia history without recurrence in the subsequent pregnancy was NRPE group. The clinical data was analyzed in the two group. Results In the population studied, the incidence of preeclampsia was 6.6% (1182/17939);in those who have a history of preeclampsia , preeclampsia recurrence rate was 45.1% (37/82). Preeclampsia recurrence factors: the maternal foundation: in 82 patients with a history of preeclampsia , 43.9% (36/82) were combined with medical disease, in which 34.1% (28/82) were combined with chronic hypertension;in RPE group medical diseases combined accounted for 67.6% (35/37),chronic hypertension accounted for 54.1% (20/37) , both of which were significantly higher than NRPE group (P<0.001、P=0.001). Previous preeclampsia pregnancy: the highest systolic blood pressure (P=0.009) and maximum diastolic blood pressure (P = 0.004) of previous preeclampsia in RPE group were significantly higher than NRPE group; the proportion of previous severe hypertension in RPE group was significantly higher than in NRPE group (P=0.007). Prenatal care:the proportion of regular antenatal care in RPE group was significantly lower than that in NRPE group (P= 0.020); the proportion of regular antenatal care in tertiary hospital was significantly lower than NRPE group (P<0.001).Multivariate logistic regression analysis showed that patients with chronic hypertension (adjusted OR=7.00, 95% CI 2.27，21.52) and irregular prenatal care (adjusted OR=4.19, 95% CI 1.14，15.42) were independent risk factors of preeclampsia recurrence. Conclusion Chronic hypertension and irregular prenatal care are independent risk factors of preeclampsia recurrence. Maternal underlying disease is an important factor in preeclampsia morbidity and relapse.
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