The role of lipid intervention in early prevention of preeclampsia.

doi:10.7504/fk2014090111

Abstract

Abstract:

Abstract: In order to maintain the pregnancy、 fetal growth and development， postpartum nursing and other special requirements, a certain amount of fat reserving during pregnancy is important. But the study showed that compared with normal pregnant women,the blood lipid level in patients with preeclampsia increases obviously. Dyslipidemia may cause the development of preeclampsia through oxidative stress, inflammatory reaction and so on,which damages vascular endothelial cell function.So early intervention and blood lipids control through diet and exercise intervention and necessary medication is necessary, and a reasonable diet and proper exercise during pregnancy plays an important role in the prevention of preeclampsia, but lipid-lowering drugs during pregnancy still needs a lot of evidence to confirm.

Key words: preeclampsia, dyslipidemia, body mass index, reasonable diet, proper exercise

摘要：

为了维持妊娠的正常进行、胎儿生长发育、产后哺乳等特殊需求，孕期必须有一定量的脂肪储备。正常妊娠期间血脂高于正常，但研究表明，子痫前期患者较正常孕妇血脂水平明显增高。血脂异常可能通过氧化应激、炎性反应等损伤血管内皮细胞功能，引起子痫前期的发展。孕前早期通过饮食控制、运动干预及必要的药物治疗控制血脂在正常范围，并且孕期合理饮食、适当运动对预防子痫前期的发生具有重要作用，但孕期药物降脂是否合理仍需大量证据进一步证实。

关键词: 子痫前期, 血脂异常, 体重指数, 合理饮食, 运动调整

CLC Number:

R714.24+4

YANG Yang,MENG Tao.. The role of lipid intervention in early prevention of preeclampsia.[J]. Acta Metallurgica Sinica, DOI: 10.7504/fk2014090111.

杨扬，孟涛. 血脂干预对子痫前期早期预防作用[J]. 中国实用妇科与产科杂志, DOI: 10.7504/fk2014090111.

References

[1］ Cartwright JE,Fraser R,Leslie K,et al.Remodelling at the maternal-fetal interface:relevance to human pregnancy disorders［J］.Reproduction,2010,140(6):803-813.

[2］ Magnussen EB, Vatten LJ, Lund-Nilsen TI, et al. Prepregnancy cardiovascular risk factors as predictors of preeclampsia:population based cohort study［J］.BMJ,2007,335(7627):978.

[3］ Shahzya SH , Naveed S,Dilys JF. Lipoprotein metabolism and vascular complications in pregnancy［J］. Clin Lipidol,2009,4(1):91-102.

[4］ Wiznitzer A,Mayer A,Novack V, et al. Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study［J］. Am J Obstet Gynecol,2009,201(5):482.e1-e8.

[5］ Sattar N,Bendomir A, Berry C ,et al.Lipoprotein subfraction concentrations in preeclampsia:pathogenic parallels to atherosclerosis［J］.Obstet Gynecol,1997,89:403-408.

[6］ Karr JE,Alexander JE,Winningham RG.Omega-3 polyunsaturated fatty acids and cognition throughout the lifespan:a review［J］.Nutr Neutosci,2011,14(5):216.

[7］ Tian C, Fan C, Liu X,et al .Brain histological changes in young mice submitted to diets with different ratios of n-6/n-3 polyunsaturated fatty acids during maternal pregnancy and lactation［J］.Clin Nutr,2011,30(5):659.

[8］ Ghio A,Bertolotto A,Resi V,et al.Triglyceride metabolism in pregnancy［J］.Adv Clin Chem,2011,55:133-135.

[9］ Roberts JM, Hubel CA.The two strange model of preeclampsia:variations on the theme［J］.Placenta,2009,30(Suppl A):532-537.

[10 ］ Cararino C,Rebelo I,Belo L, et al. Fetal lipoprotein changes in preeclampsia［J］.Acta Obstet Gynecol Scand,2008,87(6):628-634.

[11］ Risto K.Lipid abnormalities in preeclampsia:implications for vascular health［J］.Clin Lipidol,2011,6(1):33-39.

[12］ Sudhir K.Lipoprotein-associated phospholipase a2α,vascular inflammation and cardiovascular risk prediction［J］.Vasc Health Risk Manag,2006,2(2):153-156.

[13］ Shaaban YH, Aletebi F, Helal M, et al. Evaluation of the atherogenic role of lipoproteins and oxidized low-density lipoprotein in pre-eclampsia［J］. Evidence Based Women’s Health J,2012,2(4):142-146.

[14］ Kim F, Tysseling KA, Rice J,et al.Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta［J］.Arterioscler Thromb Vasc Biol,2005,25:989-994.

[15］ Londe-Agudelo A,Belizan JM.Risk factors for preeclampsia in a large cohort of Latin American and Laribkean women［J］.Br J Obstet Gynecol,2010,107(1):75-83.

[16］ Shirazian T ,Monteith S, Friedman F, et al. Lifestyle modification program decreases pregnancy weight gain in obese women［J］.Am J Perinatol ,2010,27(5):411-414.

[17］国际生命科学学会中国办事处中国肥胖问题工作组联合数据汇总分析协作组.中国成人体质指数分类的推荐意见简介［J］.中华预防医学，2001，3（5）：349-350.

[18］ Girardi ,Guillermina.Can statins prevent pregnancy complications?［J］.J Reprod Immunol,2014,101-102:161-167.

[19］ Winterfeld U,Allignol A,Panchaud A,et al. Pregnancy outcome following maternal exposure to statins: a multicentre prospective study［J］. BJOG,2013,4(120):463-471.

[1]	. [J]. Chinese Journal of Practical gynecology ang obstetric, 2022, 38(5): 534-537.
[2]	WANG Yi-nan, LI Xiao-tian. Study on the correlation between the heterogeneity of clinical presentation and pathogenesis of preeclampsia. [J]. Chinese Journal of Practical gynecology ang obstetric, 2022, 38(2): 138-141.
[3]	HE Ying-dong, CHEN Qian. HELLP syndrome without preeclampsia. [J]. Chinese Journal of Practical gynecology ang obstetric, 2022, 38(2): 145-149.
[4]	. [J]. Chinese Journal of Practical gynecology ang obstetric, 2022, 38(1): 13-17.
[5]	. [J]. Acta Metallurgica Sinica, 2021, 37(5): 505-511.
[6]	. [J]. Acta Metallurgica Sinica, 2021, 37(5): 512-514.
[7]	XIAO Xi-rong，LI Xiao-tian. Clinical limitations and practical exploration direction of sFlt-1/PlGF for PE prediction. [J]. Acta Metallurgica Sinica, 2021, 37(5): 515-519.
[8]	HE Ying-dong，CHEN Qian. Prevention of preeclampsia with low-dose aspirin：limitations and clinical selectivity. [J]. Acta Metallurgica Sinica, 2021, 37(5): 519-522.
[9]	ZHANG Qin-jian，YAN Jian-ying. Early prevention and control of preeclampsia in primary level medical institutions. [J]. Acta Metallurgica Sinica, 2021, 37(5): 522-526.
[10]	GAO Jin-song，LIU Jun-tao. Important clinical points in the prevention of preeclampsia in pregnant women with medical complications. [J]. Acta Metallurgica Sinica, 2021, 37(5): 526-531.
[11]	SHEN Hong-fei，LI Jia-po. Prevention and management of preeclampsia in twin pregnancies. [J]. Acta Metallurgica Sinica, 2021, 37(5): 531-535.
[12]	HE Jing，HONG Yan-yu. Management of early-onset preeclampsia in hospitals at different levels. [J]. Acta Metallurgica Sinica, 2021, 37(5): 539-542.
[13]	LIU Xiao-xia，ZOU Li. Enhancing cognition and management of postpartum preeclampsia and HELLP syndrome. [J]. Acta Metallurgica Sinica, 2021, 37(5): 542-546.
[14]	XU Huang-fang，LI Xiao-tian. Risk and prevention of long-term cardiovascular diseases and other diseases in preeclampsia. [J]. Acta Metallurgica Sinica, 2021, 37(2): 142-145.
[15]	HE Ying-dong，CHEN Qian. Recurrent preeclampsia. [J]. Acta Metallurgica Sinica, 2021, 37(2): 145-149.