Abstract: Fetal - placental unit ischemia and hypoxia caused by placental insufficiency is one of the important links in the pathogenesis of preeclampsia（PE）. The series of changes produced by vasoactive factors in response to hypoxia can serve as an important method of predicting，diagnosis and monitoring PE. The ratio of sFlt-1，a splice variant of FMS like tyrosine kinase 1（Flt-1），and placental growth factor（PlGF）（sflt1/PlGF）has a high negative predictive value in predicting PE.Meanwhile，sflt1/PlGF also has great value in preeclampsia diagnosis and condition monitoring. However，there are still many problems to be solved. In this paper，the recent research achievements in this field will be summarized，some limitations will be discussed，and the direction of clinical practice will be discussed.

Key words: preeclampsia, prediction, sFlt-1, PlGF, sFlt-1/PlGF

摘要： 胎盘灌注不足而导致的胎儿-胎盘单位的缺血和缺氧，是子痫前期（preeclampsia，PE）发病中的重要环节之一。血管活性因子为应对缺氧产生的一系列变化可以作为预测、诊断及监测PE的重要手段。fms样酪氨酸激酶1（fms-like tyrosine kinase 1，Flt-1）的剪接变异体可溶性Flt-1（sFlt-1）及胎盘生长因子（placental growth factor，PlGF）的比值（sFlt-1/PlGF）在预测子痫前期中具有较高的阴性预测值，同时在子痫前期诊断及病情监测方面也具有一定的指导意义，但仍有许多未解的问题。文章将对该领域近年来的研究成果做一概述，并讨论当前存在的一些局限性，探讨临床实践过程中需要努力的方向。

关键词: 子痫前期, 预测, sFlt-1, PlGF, sFlt-1/PlGF