Abstract:

Abstract： Objective To research the drug sensitivity difference of ciclopirox against antifungal drug-resistant candida spices.Methods Susceptibility testing of drug-resistant candida spices was performed using the broth microdilution method (CLSI，document M27-A3) between Oct,2013 and Jan,2014.Results The minimal inhibitory concentrations (MICs) of ciclopirox against drug-resistant candida spices were still low.Conclusion The susceptibility of ciclopirox against antifungal drug-resistant candida spices were great.And ciclopirox can be used to fight against antifungal drug resistant candida spices.

Key words: ciclopirox, drug-resistant candida spices, MIC

摘要：

目的 研究环吡酮胺对耐药假丝酵母菌菌株的药物敏感情况。方法 2013年12月至2014年1月参照美国临床实验室标准化协会(CLSI)推荐的M27-A3方案的微量液基稀释法，测定环吡酮胺对120株耐药性白假丝酵母菌和7株非白假丝酵母菌的最低抑菌浓度(MIC)。结果 (1) 并没有因为菌株对其他抗真菌药物耐药而发生环吡酮胺MIC增加，相反在耐克霉唑组和耐咪康唑组还有环吡酮胺MIC值进一步降低的现象。(2) 环吡酮胺在耐咪康唑组的MIC值要低于耐克霉唑、耐氟康唑、耐伊曲康唑组的MIC值。结论 对于耐其他抗真菌药物的假丝酵母菌，可以选择使用环吡酮胺进行治疗。

关键词: 环吡酮胺, 耐药假丝酵母菌, 最低抑菌浓度