The effect of tubal infection factors and value of prophylactic salpingectomy on the carcinogenesis of fallopian tube cancer

Abstract

Abstract:

Abstract:Clinical pathology data indicated that fallopian tube infection factors may be related with the fallopian tube carcinoma and ovarian cancer, but there are not exact conclusion. Recent years, due to the theory of ovarian cancer originating from fallopian tubes, much more attention are paid to the value of prophylactic salpingectomy on the carcinogenesis of fallopian tube cancer/ovarian cancer. Current studies show that prophylactic salpingo-oophorectomy has effect on reducing the risk of ovarian cancer in BRCA1/2 gene mutation carriers, but whether this kind of treatment could reduce the risk of sporadic ovarian cancer or not, more researches need to be done. At the same time, evaluation is required to make on the value of salpingectomy reducing the risk of hereditary ovarian cancer and other abdominopelvic serous carcinoma. In addition, when application of prophylactic salpingectomy, doctors should carefully assess the comprehensive situation of patients in clinical practice, balance the benefits and risks of the operation and pursue the most benefits for patients.

Key words: primary fallopian tube carcinoma, salpingitis, infection, prophylactic salpingectomy, ovarian cancer

摘要：

临床病理资料提示，输卵管感染可能与输卵管癌、卵巢癌的发生有一定关系，但目前尚无定论。近年来“卵巢癌的输卵管起源学说”使人们日益关注输卵管预防性切除术的价值。目前研究显示，预防性附件切除能有效降低遗传性卵巢癌，尤其是BRCA1/2基因突变携带者的卵巢癌的发病风险，能否降低散发性卵巢癌的发生需进一步探讨。单纯预防性输卵管切除能否降低遗传性及散发性卵巢癌以及其他盆腹腔浆液性腺癌的发病风险也需进一步研究。临床应用预防性附件或输卵管切除时，应慎重评估患者综合情况，权衡手术获益和风险，为患者争取最大手术获益。

关键词: 原发性输卵管癌, 输卵管炎, 感染, 预防性输卵管切除, 卵巢癌

CLC Number:

R737.3

WANG Chen,XUE Feng-xia.. The effect of tubal infection factors and value of prophylactic salpingectomy on the carcinogenesis of fallopian tube cancer[J]. Acta Metallurgica Sinica.

王辰，薛凤霞. 输卵管感染与癌变及预防性输卵管切除术的价值[J]. 中国实用妇科与产科杂志.

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