Abstract: Persistent high-risk human papilloma virus （HPV） infection is a necessary condition for cervical precancerous lesions and cervical cancer.However，the definition of persistent high-risk HPV infection is not uniform，which results in varying infection rate.Although guidelines for cervical cancer screening improve gradually，screening and management measures for persistent high-risk HPV infections have not been systematically discussed.As for patients with persistent high-risk HPV infections without histological lesions，it remains a problem whether it should be treated and how it should be treated in clinical practice.This article aims to search the published literature，reviewing the definition，infection rate，management measures and prevention of persistent high-risk HPV infections.

Key words: human papilloma virus, infection of high-risk human papilloma virus, persistent, management, prevention

摘要： 持续性高危型人乳头瘤病毒（HPV）感染是子宫颈癌及其癌前病变发生的必要条件；其定义尚有分歧，因此感染率并不确切。尽管子宫颈癌筛查指南日趋完善，但关于持续性高危型HPV感染的处理举措并无系统阐述。对于无组织学病变的持续性高危型HPV感染患者，是否治疗、如何治疗亦是临床实践中的难题。文章回顾已发表文献就其定义、感染率、处理措施及预防进行阐述。

关键词: 人乳头瘤病毒, 高危型HPV感染, 持续性, 处理, 预防