Abstract: The gonadal toxicity of chemoradiotherapy may result in premature ovarian insufficiency（POI）or premature ovarian failure（POF），which can lead to loss of fertility and damaged ovarian function.With the improvement in the survival rate of young women with malignant tumors，female cancer survivors have begun to focus on their fertility and endocrine function.This article aims to discuss the mechanism of chemoradiotherapy-induced premature ovarian insufficiency and its prevention and treatment measures，which have important roles in women’s psychological health，family well-being，and social stability.

Key words: malignancy, radiotherapy, chemotherapy, premature ovarian insufficiency

摘要： 放化疗会导致早发性卵巢功能不全或卵巢早衰，从而引起女性生育能力丧失和卵巢功能受损。随着恶性肿瘤年轻女性生存率的提高，女性癌症幸存者开始关注其生育和内分泌功能。文章阐述了放化疗引起早发性卵巢功能不全的机制以及防治措施，这对女性的身心健康、家庭和睦和社会稳定具有重要的作用。

关键词: 恶性肿瘤, 放疗, 化疗, 早发性卵巢功能不全