Abstract: Neoadjuvant chemotherapy（NACT） can shrink the tumor of locally advanced cervical cancer （LACC） before surgery and decrease postoperative lymph node metastasis，positive surgical margin，parametrial infiltration and other recurrence risk factors，thus reducing the use of radiotherapy and radiotherapy doses，and shortening radiotherapy length. NACT combined with radical surgery is beneficial to the sexual quality of young patients and can be used as the first treatment option for LACC. Establishing NACT sensitivity prediction model will help us to develop individual treatment regimens for patients，which is the direction of our future study.

Key words: locally advanced cervical cancer, neoadjuvant chemotherapy, radiotherapy

摘要： 新辅助化疗（neoadjuvant chemotherapy，NACT）应用于局部晚期子宫颈癌（locally advanced cervical cancer，LACC）在术前可缩小瘤体，术后减少淋巴结转移、切缘阳性及宫旁受累等复发风险因素，从而减少术后补充放疗的需求或放疗剂量，缩短补充放疗的时间。NACT联合根治性手术有利于改善年轻患者的性生活质量，可作为LACC的首选治疗方案。建立NACT敏感性预测模型，优化LACC患者个体化的治疗，是未来临床研究的方向。

关键词: 局部晚期子宫颈癌, 新辅助化疗, 放疗