Abstract:

Puberty induction is required when early onset ovarian dysfunction occurs before puberty.Continuous treatment must be performed from adolescence to adulthood.Far adolescent induction 17β estradiol is used；initial treatment should begin at the age of 12，starting with small doses，and gradually increasing the dose in 2-3 years.For patients with late diagnosis and those who do not consider terminal heights，the estrogen-enhancing regimen can be adopted.Oral contraceptives are not used in puberty induction.The application of periodic progesterone is only possible after the use of estrogen for at least two years or after the endometrial breakthrough hemorrhage.

Key words: premature ovarian insufficiency；adolescent induction, estrogen, progesterone

摘要：

当早发性卵巢功能不全发生在青春期之前时，需要进行青春期诱导。从青春期开始至成年期间必须进行持续治疗。青春期诱导应用17β-雌二醇，初始治疗应该在12岁开始，从小剂量开始使用，并于2~3年逐渐增加剂量。对于较晚诊断的患者及不考虑终点身高的患者，可以采用雌激素加强方案。口服避孕药不应用于青春期诱导。应用雌激素至少2年或发生子宫内膜突破性出血后才可以开始应用周期性孕激素。

关键词: 早发性卵巢功能不全, 青春期诱导, 雌激素, 孕激素