中国实用妇科与产科杂志

• 专题笔谈 • 上一篇    下一篇

循环肿瘤DNA液体活检对妇科肿瘤早期筛查意义

张师前黄文倩   

  1. 作者单位:山东大学齐鲁医院妇产科,山东 济南 250012
  • 出版日期:2016-05-02 发布日期:2016-06-17

Circulating tumor DNA and liquid biopsy in early screening of gynecologic tumor.

ZHANG Shi-qian, HUANG Wen-qian.   

  1. Department of Obstetrics and Gynecology,Qilu Hospital of Shandong University,Jinan 250012,China
  • Online:2016-05-02 Published:2016-06-17

摘要:

某些妇科恶性肿瘤若能做到早期发现,会极大改善患者预后。液体活检是一种新兴技术,通过检测患者体液中某些肿瘤相关的改变,如寻找肿瘤细胞或肿瘤DNA,实现肿瘤的早期发现和诊断。该技术方法目前尚未臻成熟,仍处于临床前研究阶段。文章通过探讨循环肿瘤DNA液体活检的定义、特性、方法及应用等,综述其在妇科肿瘤早期筛查中的意义和未来的应用前景。

关键词: 循环肿瘤DNA, 妇科肿瘤, 筛查

Abstract:

Abstract: The early detection of some gynecologic malignancies can significantly improve patient’s prognosis. Liquid biopsy is a new technology that use human’s body fluid to detect tumor-relating changes,e.g., tumor cells or tumor DNAs,in order to early detect tumor status and make diagnosis, but this method is immature and still in the pre-clinical experimental stage. We discussed the definition,characteristics,methods and applications and reviewed the meaning of circulating tumor DNA detection and its future prospects.

Key words: circulating tumor DNA, gynecologic tumor, screening

中图分类号: