中国实用妇科与产科杂志

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妇科恶性肿瘤筛查中基因检测技术的应用

王泽华郭婧   

  1. 作者单位:华中科技大学同济医学院附属协和医院妇产科,湖北 武汉 430022
  • 出版日期:2016-05-02 发布日期:2016-06-17

Use of genetic testing in the screening of gynecologic malignancies.

WANG Ze-huaGUO Jing.   

  1. Department of Obstetrics and Gynecology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022, China
  • Online:2016-05-02 Published:2016-06-17

摘要:

近年来的研究认为癌症是一种基因疾病,遗传性或获得性基因缺陷可导致癌症的发生和发展。因而,基因检测技术在妇科肿瘤的筛查中显得尤为重要。目前,人乳头瘤病毒(HPV)检测已在宫颈癌筛查中广泛应用,对于遗传性卵巢癌和子宫内膜癌高危群体,也可通过检测BRCA1/2和MLH1/MSH2突变进行高危人群风险分层。

关键词: 基因检测技术, 妇科恶性肿瘤, 筛查

Abstract:

Abstract: Cancer is considered a genetic disease.Inherited or acquired genetic disorders are involved in the malignant transformation and progression of tumors.In gynecologic oncology,genetic testing has captured global attention,especially in tumor screening.Currently,HPV testing plays an essential role in cervical cancer screening;the detection of BRCA1/2 and MLH1/MSH2 mutations has been strongly recommended to stratify patients who have a high risk of developing ovarian cancer and endometrial cancer,respectively.

Key words: genetic testing, gynecologic malignancies, screening

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