关键词: 早发性卵巢功能不全, 激素补充治疗, 青春期诱导, 长期监测管理

Abstract: The greatest harm to women with premature ovarian insufficiency（POI）is reproductive function decline and premature hypoestrogenic state.Clinically，the fertility desire of most patients is not satisfied，and often needs to be completed with egg donation-IVF-ET treatment.However，ovarian endocrine functions other than reproduction in POI patients can be fully realized through hormone replacement therapy，which can effectively improve the hypoestrogenic status，prevent long-term complications，and improve the quality of life of patients.Especially for adolescent women，it is very important to induce secondary sexual characteristics，maintain sexual psychology，and promote sexual health and bone health.As long as the contraindications are excluded，POI patients should start HRT as soon as possible and insist on long-term use until the average age of menopause（50 years old），and then judge whether menopausal hormone therapy can be continued according to the MHT treatment process.

Key words: premature ovarian insufficiency, hormone replacement therapy, puberty induction, long-term monitoring and management