中国实用妇科与产科杂志

中国实用妇科与产科杂志

• 专题笔谈 • 上一篇    下一篇

早发性卵巢功能不全对神经功能影响

  

  1. 东南大学附属中大医院妇产科，江苏 南京 210009
  • 出版日期:2018-03-02 发布日期:2018-03-09
  • 通讯作者: 任慕兰

Influence of premature ovarian insufficiency on neurological function

  1. Zhongda Hospital Affiliated to Southeast University，Nanjing 210009，China
  • Online:2018-03-02 Published:2018-03-09

摘要：

多数观察性研究表明，低雌激素状态对精神神经功能和认知功能有影响，在早发性卵巢功能不全（POI）患者表现更为明显，但直接的研究证据或高级别循证医学研究的评估资料有限。对POI患者尽早开始激素补充治疗有利于预防或减缓神经功能的退化或下降，但并不能完全纠正过早的卵巢功能衰退和绝经对神经功能的负面影响。重视POI发生和进展的各项影响因素，尽可能减缓病程进展，是防范POI患者神经功能损伤的首要措施。

关键词: 早发性卵巢功能不全, 神经功能, 激素补充治疗

Abstract:

The majority of observational studies shows that estrogen deficiency may result in negative effects on neurological function，especially in patients with premature ovarian insufficiency（POI）.However，the direct evidence and the strong quality of evidence is limited.Early onset of hormone replacement treatment in POI is beneficial to preventing cognitive decline or low cognitive function，but it can’t completely correct the negative effects on neurological function caused by POI and menopause.Taking the influencing factors of occurrence and progression of POI seriously and slowing down the progress of the disease as far as possible，are the most important measures to prevent the damage to neurological function caused by POI.

Key words: premature ovarian insufficiency, nerve function, hormone replacement therapy

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