中国实用妇科与产科杂志

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促性腺激素释放激素激动剂治疗与骨量丢失

张绍芬   

  1. 作者单位:复旦大学附属妇产科医院,上海200011 
  • 出版日期:2014-05-02 发布日期:2014-05-06

Gonadotropin-releasing hormone agonist treatment and bone loss

Zhang Shao-fen   

  1. Department of Gynecology,Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200011,China
     
  • Online:2014-05-02 Published:2014-05-06

摘要:

促性腺激素释放激素激动剂(GnRH-a)已广泛应用于妇科子宫内膜异位症、子宫肌瘤、性早熟等雌激素依赖性疾病的治疗。但其导致的低雌激素血症与骨丢失也愈来愈引起人们的认识和重视。GnRH-a与HRT反向添加疗法可以降低骨丢失、改善生活质量,从而延长GnRH-a治疗时间。

关键词: 促性腺激素释放激素激动剂, 骨丢失, 反向添加疗法, 激素补充治疗 

Abstract:

Abstract:Gonadotropin-releasing hormone agonist (GnRHa) has been widely used in the treatment of the endometriosis,uterine myoma and precocious puberty.However long-term GnRHa treatment can induce a hypoestrogenic state and loss of bone mineral density. GnRHa and add-back therapy with HRT can reduce bone mass loss,improve quality of life and prolong GnRHa treatment duration.

Key words: GnRH-a;bone loss, add-back therapy, HRT

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