中国实用妇科与产科杂志 ›› 2022, Vol. 38 ›› Issue (5): 491-495.DOI: 10.19538/j.fk2022050104

• 专题笔谈 • 上一篇    下一篇

复发性卵巢子宫内膜异位症的管理

  

  1. 北京大学第一医院妇产科,北京 100034
  • 出版日期:2022-05-02 发布日期:2022-05-02
  • 通讯作者: 周应芳
  • 基金资助:
    国家重点研发计划(2017YFC1001200)

Management of recurrent ovarian endometriosis.

  1. Department of Obstetrics and Gynecology,Peking University First Hospital,Beijing 100034,China
  • Online:2022-05-02 Published:2022-05-02

摘要: 子宫内膜异位症(内异症)是慢性复发性疾病,年复发率约10%。复发性卵巢子宫内膜异位症一般指卵巢子宫内膜异位囊肿复发,是内异症最常见的复发类型,也是导致再次手术的主要原因。治疗原则基本遵循初始治疗,但应个体化。治疗包括药物治疗和手术治疗。常用药物有孕激素类、促性腺激素释放激素激动剂(GnRH-a)、复方口服避孕药物及中医中药等。有些药物比如地诺孕素可以使复发的卵巢子宫内膜异位囊肿明显变小甚至消失,从而免去了患者承受再次手术的风险,近年来广泛推荐使用。再次手术对卵巢储备功能影响更大,术后仍易复发,部分患者也可选择超声引导穿刺治疗。对合并不孕者首先推荐辅助生殖技术。药物维持治疗及长期管理是减少卵巢子宫内膜异位囊肿复发的关键。业已证明,长期使用孕激素类、GnRH-a和复方口服避孕药等均可预防卵巢子宫内膜异位囊肿复发。

关键词: 子宫内膜异位症, 复发, 长期管理

Abstract: Endometriosis is a chronic recurrent and systemic disease with an annual recurrence rate of about 10%. Recurrent ovarian endometriosis generally refers to the recurrence of ovarian endometrioma, which is the most common recurrence type of endometriosis and the main reason for reoperation. The treatment principle basically follows the initial treatment, but should be individualized. Treatment includes both medical and surgical treatment. The drugs commonly used include progestins, gonadotropin releasing hormone agonist(GnRH-a), compound oral contraceptives and traditional Chinese medicine. Some drugs, such as dienogest, can significantly reduce the size recurrent ovarian endometrioma or even make it disappear, thus avoiding the risk of reoperation,which has been widely recommended in recent years.Reoperation has a greater negative impact on ovarian reserve function,and it is still very likely to have relapse after reoperation. Some patients can also choose ultrasound-guided puncture therapy. IVF is first recommended for patients with infertility. Drug maintenance therapy and long-term management are the key to reducing the recurrence of ovarian endometrioma. It has been proved that long-term use of progestins,GnRH-a and compound oral contraceptives can prevent the recurrence of ovarian endometrioma.

Key words: endometriosis, recurrence, long-term management

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